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Query: SH2B1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SH2B1 0 0.369 0.970 0.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SH2B1 Phosphorylation S125 0.018 0.257 _S(ph)SEDLAGPLPSSVSSSSTTSSKPK_
SH2B1 Phosphorylation S126 0.018 0.257 _S(ph)SEDLAGPLPSSVSSSSTTSSKPK_
SH2B1 Phosphorylation S96 0.112 -0.143 _ASGSLSPPILAPLS(ph)PGAEISPHDLSLESCR_

Background Information for SH2B1:


Pubmed-SH2B1 »
Uniprot-SH2B1 »
Biogrid-SH2B1 »
ProteomicsDB-SH2B1 »

Tumorportal-SH2B1 »
COSMIC-SH2B1 »
GenomeRNAi-SH2B1 »
Genecards-SH2B1


Protein-protein Interactions for SH2B1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SH2B1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members SH2 IPR000980 0.05
Category members Phe_ZIP IPR015012 0


Protein complexes (CORUM database) featuring SH2B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SH2B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members Pathway Pathway_974 REACTOME_PROLACTIN_RECEPTOR_SIGNALING 0 0.13
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_1134 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0045840 positive regulation of mitosis Database 0


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