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Query: SETD2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SETD2 3 7.504 -1.690 2.960 1.619 1.725 -0.978 0.379

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SETD2 Phosphorylation T1083 0.552 _NSTLPMEET(ph)SPCSSR_
SETD2 Phosphorylation S624 0.374 0.432 _LNDS(ph)PTLKK_
SETD2 Phosphorylation S1885 0.110 _IIS(ph)ENSMDSAISDATSELEGK_
SETD2 Phosphorylation S1888 1.247 0.067 _IISENS(ph)M(ox)DSAISDATSELEGK_
SETD2 Phosphorylation S1084 -0.102 _NSTLPMEETS(ph)PCSSR_
SETD2 Phosphorylation S131 -0.001 -0.163 _M(ox)EIGDTLSTAEESS(ph)PPK_
SETD2 Phosphorylation T1872 -0.148 -1.034 _LSTEADTDT(ph)PKK_
SETD2 Phosphorylation S742 -1.167 -1.779 _S(ph)ESPFRETEPLVSPHQDK_
SETD2 Phosphorylation S130 -0.443 _M(ox)EIGDTLSTAEES(ph)SPPK_
SETD2 Phosphorylation S708 0.398 _TDAVLM(ox)TSDDSVTGSELS(ph)PLVK_
SETD2 Phosphorylation S744 -0.557 _SES(ph)PFRETEPLVSPHQDK_

Background Information for SETD2:


Pubmed-SETD2 »
Uniprot-SETD2 »
Biogrid-SETD2 »
ProteomicsDB-SETD2 »

Tumorportal-SETD2 »
COSMIC-SETD2 »
GenomeRNAi-SETD2 »
Genecards-SETD2


Protein-protein Interactions for SETD2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RASSF8 Cat. description Hein, Mann, Cell 2015
Category members IP bait SETD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOGA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TTLL7 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGEF10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRPLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPB8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JMJD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSBN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCARA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SETD2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members SET_dom IPR001214 0.29
Category members Post-SET_dom IPR003616 0.03
Category members AWS_dom IPR006560 0
Category members Ferritin-like_SF IPR009078 0


Protein complexes (CORUM database) featuring SETD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SETD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0060977 coronary vasculature morphogenesis Database 0.13
Category members GO Category GO:0018023 peptidyl-lysine trimethylation Database 0.11
Category members GO Category GO:0010452 histone H3-K36 methylation Database 0.03
Category members GO Category GO:0048864 stem cell development Database 0.03
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members Disease phenotype RENAL_CELL_CARCINOMA_NONPAPILLARY RENAL CELL CARCINOMA NONPAPILLARY Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0001763 morphogenesis of a branching structure Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010793 regulation of mRNA export from nucleus Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0035441 cell migration involved in vasculogenesis Database 0
Category members GO Category GO:0048332 mesoderm morphogenesis Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0060039 pericardium development Database 0
Category members GO Category GO:0060669 embryonic placenta morphogenesis Database 0


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