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Query: SEC61A1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SEC61A1 2 11.096 1.170 -1.120 0.304 0.263

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SEC61A1 Ubiquitylation K394 1.586 _TWIEVSGSSAK(gl)DVAK_
SEC61A1 Phosphorylation S414 0.827 _ETS(ph)MVHELNR_
SEC61A1 Ubiquitylation K401 -1.030 0.553 _QLK(gl)EQQMVMR_
SEC61A1 Ubiquitylation K398 0.253 _DVAK(gl)QLK_
SEC61A1 Ubiquitylation K113 -0.118 _IIEVGDTPK(gl)DR_

Background Information for SEC61A1:


Pubmed-SEC61A1 »
Uniprot-SEC61A1 »
Biogrid-SEC61A1 »
ProteomicsDB-SEC61A1 »

Tumorportal-SEC61A1 »
COSMIC-SEC61A1 »
GenomeRNAi-SEC61A1 »
Genecards-SEC61A1


Protein-protein Interactions for SEC61A1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait PCGF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UPF3B Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAZ Cat. description Hein, Mann, Cell 2015


Protein Domains in SEC61A1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SecY/SEC61-alpha IPR002208 0.38
Category members Translocon_Sec61/SecY_plug_dom IPR019561 0.38
Category members SecY_su_dom IPR023201 0.38


Protein complexes (CORUM database) featuring SEC61A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SEC61A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0006620 posttranslational protein targeting to membrane Database 0.93
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0045047 protein targeting to ER Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members GO Category GO:0007029 endoplasmic reticulum organization Database 0.05
Category members GO Category GO:0005791 rough endoplasmic reticulum Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0030176 integral to endoplasmic reticulum membrane Database 0
Category members GO Category GO:0034341 response to interferon-gamma Database 0


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