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Query: SDHB

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SDHB 0 1.555 -0.720 0.810 -0.156 -0.332 -1.201 0.467 0.434

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for SDHB:


Pubmed-SDHB »
Uniprot-SDHB »
Biogrid-SDHB »
ProteomicsDB-SDHB »

Tumorportal-SDHB »
COSMIC-SDHB »
GenomeRNAi-SDHB »
Genecards-SDHB


Protein-protein Interactions for SDHB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACN9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait D2HGDH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFAB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SDHB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 2Fe-2S_ferredoxin-type IPR001041 0
Category members Helical_ferredxn IPR009051 0


Protein complexes (CORUM database) featuring SDHB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SDHB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members Pathway Pathway_12 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE 0 1.87
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_50 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 0 0.7
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006105 succinate metabolic process Database 0.31
Category members Disease phenotype Gastrointestinal_stromal_tumor Gastrointestinal stromal tumor Database 0.22
Category members Pathway Pathway_49 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT 0 0.17
Category members GO Category GO:0022904 respiratory electron transport chain Database 0.15
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0009060 aerobic respiration Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members Disease phenotype COWDEN_SYNDROME COWDEN SYNDROME Database 0.03
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_30 KEGG_OXIDATIVE_PHOSPHORYLATION 0 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members Pathway Pathway_48 BIOCARTA_ETC_PATHWAY 0 0
Category members Disease phenotype Carney-Stratakis_syndrome Carney-Stratakis syndrome Database 0
Category members Disease phenotype Hereditary_pheochromocytoma-paraganglioma Hereditary pheochromocytoma-paraganglioma Database 0
Category members Disease phenotype Isolated_succinate-CoQ_reductase_deficiency Isolated succinate-CoQ reductase deficiency Database 0
Category members Disease phenotype PARAGANGLIOMA_AND_GASTRIC_STROMAL_SARCOMA PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA Database 0
Category members Disease phenotype PHEOCHROMOCYTOMA PHEOCHROMOCYTOMA Database 0
Category members GO Category GO:0005749 mitochondrial respiratory chain complex II Database 0
Category members GO Category GO:0008177 succinate dehydrogenase (ubiquinone) activity Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048039 ubiquinone binding Database 0
Category members GO Category GO:0051536 iron-sulfur cluster binding Database 0
Category members GO Category GO:0051537 2 iron, 2 sulfur cluster binding Database 0
Category members GO Category GO:0051538 3 iron, 4 sulfur cluster binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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