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Query: PRPF19

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRPF19 0 0.222 -0.460 0.190 -0.179 -0.151 -0.246

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRPF19 Ubiquitylation K261 -1.023 0.257 _SSEQILATLK(gl)GHTK_
PRPF19 Ubiquitylation K122 0.200 _LTK(gl)EVTAAR_

Background Information for PRPF19:


Pubmed-PRPF19 »
Uniprot-PRPF19 »
Biogrid-PRPF19 »
ProteomicsDB-PRPF19 »

Tumorportal-PRPF19 »
COSMIC-PRPF19 »
GenomeRNAi-PRPF19 »
Genecards-PRPF19


Protein-protein Interactions for PRPF19
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC12 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRNKL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait SNW1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C2orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGCR14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDEL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLRG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPIE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRPF19
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Ricin_B_lectin IPR000772 0.18
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Ubox_domain IPR003613 0


Protein complexes (CORUM database) featuring PRPF19
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 1182 CDC5L core complex Database 0.08


Categories featuring PRPF19
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0000245 spliceosomal complex assembly Database 0.39
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0008610 lipid biosynthetic process Database 0.05
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0048026 positive regulation of mRNA splicing, via spliceosome Database 0.04
Category members GO Category GO:0000974 Prp19 complex Database 0
Category members GO Category GO:0001833 inner cell mass cell proliferation Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0034450 ubiquitin-ubiquitin ligase activity Database 0
Category members GO Category GO:0048711 positive regulation of astrocyte differentiation Database 0


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