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Query: PPP6C

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP6C 0 -0.242 0.340 -0.620 0.715 -0.944 -0.116 0.577

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP6C Ubiquitylation K25 -0.474 _YLPENDLK(gl)R_

Background Information for PPP6C:


Pubmed-PPP6C »
Uniprot-PPP6C »
Biogrid-PPP6C »
ProteomicsDB-PPP6C »

Tumorportal-PPP6C »
COSMIC-PPP6C »
GenomeRNAi-PPP6C »
Genecards-PPP6C


Protein-protein Interactions for PPP6C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANKRD28 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TYW3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANKRD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP6C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP6C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5196 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Database 1.67


Categories featuring PPP6C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Human mutations pubmedid:22817889 A Landscape of Driver Mutations in Melanoma (Hodis et al, Cell 2012) Research article 0.15
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members Human mutations pubmedid:22842228 Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. (Krauthammer et al, Nat. Genet. 2012 Research article 0


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