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Query: PNPT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PNPT1 1 4.168 -1.420 2.630 1.469 -0.694 0.280 0.483

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for PNPT1:


Pubmed-PNPT1 »
Uniprot-PNPT1 »
Biogrid-PNPT1 »
ProteomicsDB-PNPT1 »

Tumorportal-PNPT1 »
COSMIC-PNPT1 »
GenomeRNAi-PNPT1 »
Genecards-PNPT1


Protein-protein Interactions for PNPT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACAD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAHD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINA12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUPV3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBRG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMED2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PNPT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members KH_dom IPR004087 0.23
Category members ExoRNase_PH_dom1 IPR001247 0.23
Category members ExoRNase_PH_dom2 IPR015847 0.23
Category members Rbsml_prot_S1_RNA-bd_dom IPR003029 0.15
Category members S1_dom IPR022967 0.15
Category members KH_dom_type_1 IPR004088 0.13


Protein complexes (CORUM database) featuring PNPT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PNPT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0035928 rRNA import into mitochondrion Database 0.35
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0070207 protein homotrimerization Database 0.16
Category members GO Category GO:0000964 mitochondrial RNA 5'-end processing Database 0.15
Category members GO Category GO:0043631 RNA polyadenylation Database 0.1
Category members GO Category GO:0043457 regulation of cellular respiration Database 0.08
Category members Disease phenotype Autosomal_recessive_nonsyndromic_sensorineural_deafness_type_DFNB Autosomal recessive nonsyndromic sensorineural deafness type DFNB Database 0.04
Category members GO Category GO:0006402 mRNA catabolic process Database 0.02
Category members GO Category GO:0000175 3'-5'-exoribonuclease activity Database 0
Category members GO Category GO:0000958 mitochondrial mRNA catabolic process Database 0
Category members GO Category GO:0000962 positive regulation of mitochondrial RNA catabolic process Database 0
Category members GO Category GO:0000965 mitochondrial RNA 3'-end processing Database 0
Category members GO Category GO:0006401 RNA catabolic process Database 0
Category members GO Category GO:0008266 poly(U) RNA binding Database 0
Category members GO Category GO:0034046 poly(G) RNA binding Database 0
Category members GO Category GO:0034599 cellular response to oxidative stress Database 0
Category members GO Category GO:0035198 miRNA binding Database 0
Category members GO Category GO:0035458 cellular response to interferon-beta Database 0
Category members GO Category GO:0045025 mitochondrial degradosome Database 0
Category members GO Category GO:0045926 negative regulation of growth Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0061014 positive regulation of mRNA catabolic process Database 0
Category members GO Category GO:0070584 mitochondrion morphogenesis Database 0


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