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Query: PIAS4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIAS4 0 -0.072 -1.510 2.250 -1.454

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIAS4 Ubiquitylation K57 0.068 -0.936 _ALQLVQFDCSPELFKK(gl)_
PIAS4 Ubiquitylation K330 -1.699 _VSLICPLVK(gl)MR_
PIAS4 Ubiquitylation K125 -2.654 _LPAK(gl)TLKPEVR_

Background Information for PIAS4:


Pubmed-PIAS4 »
Uniprot-PIAS4 »
Biogrid-PIAS4 »
ProteomicsDB-PIAS4 »

Tumorportal-PIAS4 »
COSMIC-PIAS4 »
GenomeRNAi-PIAS4 »
Genecards-PIAS4


Protein-protein Interactions for PIAS4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CA10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIAS4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members Znf_MIZ IPR004181 0.13


Protein complexes (CORUM database) featuring PIAS4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PIAS4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0033235 positive regulation of protein sumoylation Database 0.61
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0019789 SUMO ligase activity Database 0.05
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0


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