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Query: PABPC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PABPC1 0 0.747 0.100 -0.400 0.167 -0.387 -0.147 -0.312 -0.037

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PABPC1 Ubiquitylation K78 -0.883 0.807 _ALDTMNFDVIK(gl)GKPVR_
PABPC1 Ubiquitylation K95 -0.105 0.553 _K(gl)SGVGNIFIK_
PABPC1 Ubiquitylation K108 -0.071 0.530 _NLDK(gl)SIDNK_
PABPC1 Ubiquitylation K279 -0.143 0.326 _K(gl)FEQMK(gl)QDR_
PABPC1 Ubiquitylation K284 -0.108 0.322 _K(gl)FEQMK(gl)QDR_
PABPC1 Ubiquitylation K512 -0.640 0.085 _TVPQYK(gl)YAAGVR_
PABPC1 Ubiquitylation K188 -0.826 -0.017 _AK(gl)EFTNVYIK_
PABPC1 Ubiquitylation K104 -0.977 -0.336 _SGVGNIFIK(gl)NLDK_
PABPC1 Ubiquitylation K138 -0.960 _VVCDENGSK(gl)GYGFVHFETQEAAER_
PABPC1 Ubiquitylation K157 -0.582 _AIEK(gl)MNGMLLNDRK_
PABPC1 Ubiquitylation K213 -0.170 _DLFGK(gl)FGPALSVK_
PABPC1 Ubiquitylation K231 0.080 _SK(gl)GFGFVSFER_
PABPC1 Ubiquitylation K259 -0.125 _ELNGK(gl)QIYVGR_
PABPC1 Ubiquitylation K312 0.122 _K(gl)EFSPFGTITSAK_
PABPC1 Ubiquitylation K361 -0.142 _IVATK(gl)PLYVALAQR_

Background Information for PABPC1:


Pubmed-PABPC1 »
Uniprot-PABPC1 »
Biogrid-PABPC1 »
ProteomicsDB-PABPC1 »

Tumorportal-PABPC1 »
COSMIC-PABPC1 »
GenomeRNAi-PABPC1 »
Genecards-PABPC1


Protein-protein Interactions for PABPC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GSPT1;GSPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PABPC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSPT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRA2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PABPC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members RRM_dom_euk IPR003954 0.18
Category members PABP_HYD IPR002004 0
Category members PABP_1234 IPR006515 0


Protein complexes (CORUM database) featuring PABPC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1307 Multiprotein complex (mRNA turnover) Database 0.21
Category members Corum 1308 PABPC1-HSPA8-HNRPD-EIF4G1 complex Database 0.04


Categories featuring PABPC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_776 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 0 1.45
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008143 poly(A) RNA binding Database 0.44
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_841 REACTOME_DEADENYLATION_OF_MRNA 0 0
Category members GO Category GO:0008494 translation activator activity Database 0
Category members GO Category GO:0031047 gene silencing by RNA Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0048255 mRNA stabilization Database 0
Category members GO Category GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Database 0


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