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Query: NUDT21

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NUDT21 0 2.528 -0.700 0.830 0.214 -0.359 0.236 0.333 0.307

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NUDT21 Ubiquitylation K56 -1.058 0.450 _EPLYEK(gl)DSSVAAR_
NUDT21 Ubiquitylation K29 -0.121 -0.076 _YIQQTK(gl)PLTLER_
NUDT21 Ubiquitylation K192 -0.730 -0.836 _ALFAVPKNYK(gl)_
NUDT21 Ubiquitylation K73 0.158 _MREEFDK(gl)IGMR_
NUDT21 Ubiquitylation K122 -1.445 _LPGGELNPGEDEVEGLK(gl)R_
NUDT21 Ubiquitylation K189 -0.510 _ALFAVPK(gl)NYK_

Background Information for NUDT21:


Pubmed-NUDT21 »
Uniprot-NUDT21 »
Biogrid-NUDT21 »
ProteomicsDB-NUDT21 »

Tumorportal-NUDT21 »
COSMIC-NUDT21 »
GenomeRNAi-NUDT21 »
Genecards-NUDT21


Protein-protein Interactions for NUDT21
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CPSF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUDT21 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait STMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JMJD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NUDT21
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NUDIX_hydrolase_dom-like IPR015797 0


Protein complexes (CORUM database) featuring NUDT21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1769 CPSF6-ITCH-NUDT21-POLR2A complex Database 0.85
Category members Corum 1767 CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.43
Category members Corum 1768 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.23


Categories featuring NUDT21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members Pathway Pathway_855 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 0 0.29
Category members GO Category GO:0042382 paraspeckles Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0005849 mRNA cleavage factor complex Database 0.13
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members Pathway Pathway_853 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 0 0.05
Category members GO Category GO:0017091 AU-rich element binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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