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Query: NONO

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NONO 0 2.375 -1.510 2.340
NONO 0 2.375 -1.510 2.340 -0.053 0.223 -0.198 -0.033 -0.027

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NONO Ubiquitylation K109 0.479 0.300 _DK(gl)GFGFIR_
NONO Ubiquitylation K279 0.027 -0.480 _ALIEMEK(gl)QQQDQVDR_
NONO Ubiquitylation K198 0.167 -0.607 _GIVEFSGK(gl)PAAR_
NONO Ubiquitylation K467 -0.128 -0.646 _AAPGAEFAPNK(gl)R_
NONO Phosphorylation T450 0.010 -0.660 _FGQAATM(ox)EGIGAIGGT(ph)PPAFNR_
NONO Ubiquitylation K5 0.390 -0.727 _(ac)MQSNK(gl)TFNLEK_
NONO Ubiquitylation K96 0.095 -0.745 _KLFEK(gl)YGK_
NONO Ubiquitylation K371 -0.098 -0.962 _RQQEGFK(gl)GTFPDAR_
NONO Ubiquitylation K336 0.158 -0.998 _MEELHNQEVQK(gl)R_
NONO Ubiquitylation K107 -1.009 _AGEVFIHK(gl)DK_
NONO Ubiquitylation K243 0.302 -1.020 _LVIK(gl)NQQFHK_
NONO Ubiquitylation K11 0.290 -1.060 _TFNLEK(gl)QNHTPR_
NONO Ubiquitylation K99 0.301 -1.179 _YGK(gl)AGEVFIHK_
NONO Phosphorylation T428 -2.034 _GAM(ox)PPAPVPAGTPAPPGPATMMPDGTLGLT(ph)PPTTER_
NONO Ubiquitylation K190 -1.285 -2.164 _GRPSGK(gl)GIVEFSGKPAAR_
NONO Ubiquitylation K68 -0.317 _KPGEK(gl)TFTQR_
NONO Ubiquitylation K272 0.498 _WK(gl)ALIEMEK_

Background Information for NONO:


Pubmed-NONO »
Uniprot-NONO »
Biogrid-NONO »
ProteomicsDB-NONO »

Tumorportal-NONO »
COSMIC-NONO »
GenomeRNAi-NONO »
Genecards-NONO


Protein-protein Interactions for NONO
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CXXC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASAH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NONO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINA12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NONO
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members NOPS IPR012975 0


Protein complexes (CORUM database) featuring NONO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3137 MASH1 promoter-coactivator complex Database 5.32
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 1760 TOP1-PSF-P54 complex Database 0.17
Category members Corum 335 p54(nrb)-PSF-matrin3 complex Database 0.17
Category members Corum 3142 CAMK2-delta-MASH1 promoter-coactivator complex Database 0.07
Category members Corum 1148 snRNP-free U1A (SF-A) complex Database 0.05
Category members Corum 330 PSF-p54(nrb) complex Database 0.04


Categories featuring NONO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0042382 paraspeckles Database 0.23
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members Disease phenotype Translocation_renal_cell_carcinoma Translocation renal cell carcinoma Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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