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Query: NDUFS8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NDUFS8 0 -0.475 0.480 0.100 0.556 0.300 0.534

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NDUFS8 Ubiquitylation K88 -1.865 _EPATINYPFEK(gl)GPLSPR_

Background Information for NDUFS8:


Pubmed-NDUFS8 »
Uniprot-NDUFS8 »
Biogrid-NDUFS8 »
ProteomicsDB-NDUFS8 »

Tumorportal-NDUFS8 »
COSMIC-NDUFS8 »
GenomeRNAi-NDUFS8 »
Genecards-NDUFS8


Protein-protein Interactions for NDUFS8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED2 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait ECSIT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFA13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NDUFS8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 4Fe4S-bd_dom IPR001450 0


Protein complexes (CORUM database) featuring NDUFS8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NDUFS8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003954 NADH dehydrogenase activity Database 1.02
Category members Pathway Pathway_50 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 0 0.7
Category members Disease phenotype Mitochondrial_Respiratory_Chain_Complex_I_Deficiency_(nuclear_genes) Mitochondrial Respiratory Chain Complex I Deficiency (nuclear genes) Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype Isolated_NADH-CoQ_reductase_deficiency Isolated NADH-CoQ reductase deficiency Database 0.17
Category members Pathway Pathway_49 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT 0 0.17
Category members GO Category GO:0022904 respiratory electron transport chain Database 0.15
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0008137 NADH dehydrogenase (ubiquinone) activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members Disease phenotype Leigh_syndrome_with_leukodystrophy Leigh syndrome with leukodystrophy Database 0.08
Category members GO Category GO:0005747 mitochondrial respiratory chain complex I Database 0.08
Category members GO Category GO:0006120 mitochondrial electron transport, NADH to ubiquinone Database 0.07
Category members GO Category GO:0016651 oxidoreductase activity, acting on NAD(P)H Database 0.05
Category members GO Category GO:0032981 mitochondrial respiratory chain complex I assembly Database 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_30 KEGG_OXIDATIVE_PHOSPHORYLATION 0 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members Disease phenotype Leigh_syndrome Leigh syndrome Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051536 iron-sulfur cluster binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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