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Query: NCK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCK2 0 1.267 -0.870 1.530

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCK2 Phosphorylation S90 -0.317 0.054 _DAS(ph)PTPSTDAEYPANGSGADR_

Background Information for NCK2:


Pubmed-NCK2 »
Uniprot-NCK2 »
Biogrid-NCK2 »
ProteomicsDB-NCK2 »

Tumorportal-NCK2 »
COSMIC-NCK2 »
GenomeRNAi-NCK2 »
Genecards-NCK2


Protein-protein Interactions for NCK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C20orf177 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYX1C1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRFN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NCK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members SH3_domain IPR001452 0
Category members NCK IPR017304 0


Protein complexes (CORUM database) featuring NCK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NCK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0030838 positive regulation of actin filament polymerization Database 0.21
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0042102 positive regulation of T cell proliferation Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007172 signal complex assembly Database 0
Category members GO Category GO:0007176 regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0008093 cytoskeletal adaptor activity Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0019887 protein kinase regulator activity Database 0
Category members GO Category GO:0030159 receptor signaling complex scaffold activity Database 0


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