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Query: MYH10

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYH10 0 1.409 0.740 -0.560 -0.265 -0.438
MYH10 0 1.409 0.740 -0.560 0.036 0.397 0.165

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYH10 Phosphorylation S1998 0.372 0.302 _QLHLEGASLELS(ph)DDDTESK_
MYH10 Phosphorylation S1979 -0.233 -0.052 _GGPISFS(ph)SSR_
MYH10 Phosphorylation S1981 -0.541 -0.089 _GGPISFSSS(ph)R_
MYH10 Phosphorylation S225 -0.296 _DHNIPQES(ph)PKPVK_
MYH10 Ubiquitylation K256 0.402 _QLLQANPILESFGNAKTVK(gl)_
MYH10 Ubiquitylation K899 -1.210 _QEEELQAK(gl)DEELLK_
MYH10 Phosphorylation S1980 -0.231 _GGPISFSS(ph)SR_

Background Information for MYH10:


Pubmed-MYH10 »
Uniprot-MYH10 »
Biogrid-MYH10 »
ProteomicsDB-MYH10 »

Tumorportal-MYH10 »
COSMIC-MYH10 »
GenomeRNAi-MYH10 »
Genecards-MYH10


Protein-protein Interactions for MYH10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait TECPR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYH10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17
Category members UBA-like IPR009060 0.17
Category members HR1_rho-bd IPR011072 0.07
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members Myosin_tail IPR002928 0
Category members Myosin_N IPR004009 0
Category members Myosin_S1_N IPR008989 0
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring MYH10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02


Categories featuring MYH10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0021680 cerebellar Purkinje cell layer development Database 0.44
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030898 actin-dependent ATPase activity Database 0.31
Category members GO Category GO:0030048 actin filament-based movement Database 0.28
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members GO Category GO:0000146 microfilament motor activity Database 0.27
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0007097 nuclear migration Database 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0021592 fourth ventricle development Database 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0021678 third ventricle development Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0016460 myosin II complex Database 0.03
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001778 plasma membrane repair Database 0
Category members GO Category GO:0006930 substrate-dependent cell migration, cell extension Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007512 adult heart development Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0021670 lateral ventricle development Database 0
Category members GO Category GO:0030239 myofibril assembly Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0055003 cardiac myofibril assembly Database 0
Category members GO Category GO:0055015 ventricular cardiac muscle cell development Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0


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