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Query: MSH3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MSH3 0 1.238 0.890 -0.360 -0.771 0.719 0.629 0.421 0.240

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for MSH3:


Pubmed-MSH3 »
Uniprot-MSH3 »
Biogrid-MSH3 »
ProteomicsDB-MSH3 »

Tumorportal-MSH3 »
COSMIC-MSH3 »
GenomeRNAi-MSH3 »
Genecards-MSH3


Protein-protein Interactions for MSH3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BATF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1LI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF187 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MSH3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DNA_mismatch_repair_MutS-lik_N IPR007695 0.43
Category members DNA_mmatch_repair_MutS_con_dom IPR007860 0.43
Category members DNA_mismatch_repair_MutS_N IPR016151 0.17
Category members DNA_mismatch_repair_MutS_C IPR000432 0.16
Category members DNA_mismatch_repair_MutS_core IPR007696 0.16
Category members DNA_mismatch_repair_MutS_clamp IPR007861 0.16


Protein complexes (CORUM database) featuring MSH3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 375 MSH2-MSH3 complex Database 0.17
Category members Corum 378 MutS-beta complex Database 0.17


Categories featuring MSH3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0051096 positive regulation of helicase activity Database 0.73
Category members GO Category GO:0000710 meiotic mismatch repair Database 0.54
Category members GO Category GO:0000404 loop DNA binding Database 0.43
Category members GO Category GO:0032139 dinucleotide insertion or deletion binding Database 0.43
Category members GO Category GO:0032142 single guanine insertion binding Database 0.43
Category members GO Category GO:0032357 oxidized purine DNA binding Database 0.43
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0045910 negative regulation of DNA recombination Database 0.31
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members GO Category GO:0019237 centromeric DNA binding Database 0.23
Category members Disease phenotype ENDOMETRIAL_CANCER ENDOMETRIAL CANCER Database 0.21
Category members GO Category GO:0016447 somatic recombination of immunoglobulin gene segments Database 0.21
Category members GO Category GO:0000406 double-strand/single-strand DNA junction binding Database 0.17
Category members GO Category GO:0032181 dinucleotide repeat insertion binding Database 0.17
Category members GO Category GO:0032302 MutSbeta complex Database 0.17
Category members GO Category GO:0000403 Y-form DNA binding Database 0.04
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0043570 maintenance of DNA repeat elements Database 0


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