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Query: MECOM

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MECOM 0 -0.733 0.130 -0.120 -0.189 0.565 -1.171
MECOM 0 -0.733 0.740 -0.750 -0.189 0.565 -1.171

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MECOM Phosphorylation S1039 -0.074 0.136 _NFIGNSNHGSQS(ph)PR_
MECOM Phosphorylation S62 -1.041 -0.744 _EGS(ph)PYKAPIYIPDDIPIPAEFELR_

Background Information for MECOM:


Pubmed-MECOM »
Uniprot-MECOM »
Biogrid-MECOM »
ProteomicsDB-MECOM »

Tumorportal-MECOM »
COSMIC-MECOM »
GenomeRNAi-MECOM »
Genecards-MECOM


Protein-protein Interactions for MECOM
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERMAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPDEF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MECOM
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92
Category members SET_dom IPR001214 0.29
Category members Znf_BED IPR003656 0


Protein complexes (CORUM database) featuring MECOM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MECOM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Myelodysplastic_syndromes Myelodysplastic syndromes Database 0
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0001780 neutrophil homeostasis Database 0
Category members GO Category GO:0009605 response to external stimulus Database 0
Category members GO Category GO:0009617 response to bacterium Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0035115 embryonic forelimb morphogenesis Database 0
Category members GO Category GO:0035116 embryonic hindlimb morphogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043069 negative regulation of programmed cell death Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0060039 pericardium development Database 0
Category members GO Category GO:0071425 hematopoietic stem cell proliferation Database 0


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