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Query: MDC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MDC1 3 10.065 0.550 -0.700

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MDC1 Phosphorylation S513 3.827 3.443 _S(ph)QASTTVDINTQVEK_
MDC1 Phosphorylation S1086 1.806 _TRQDGS(ph)QEAPEAPLSSELEPFHPKPK_
MDC1 Phosphorylation S168 0.788 0.909 _LLLAEDS(ph)EEEVDFLSER_
MDC1 Phosphorylation T1567 0.014 0.330 _SSVKT(ph)PESIVPIAPELQPSTSR_
MDC1 Phosphorylation S1820 0.073 0.144 _SLATMDS(ph)PPHQK_
MDC1 Phosphorylation T1671 0.063 _TPKPVEPAASDLEPFTPTDQSVT(ph)PEAIAQGGQSK_
MDC1 Phosphorylation S1419 -0.152 0.059 _LEPSTS(ph)TDQPVTPEPTSQATR_
MDC1 Phosphorylation S1775 0.591 -0.039 _AAESLTAIPEPAS(ph)PQLLETPIHASQIQK_
MDC1 Phosphorylation T404 -0.050 _SQASMVINSDT(ph)DDEEEVSAALTLAHLK_
MDC1 Phosphorylation T1425 0.018 -0.167 _LEPSTSTDQPVT(ph)PEPTSQATR_
MDC1 Phosphorylation T1157 -0.188 _SSVKT(ph)PEPVVPTAPELQPSTSTDQPVTSEPTSQVTR_
MDC1 Phosphorylation T1800 -0.475 -0.235 _SRFT(ph)PELQPK_
MDC1 Phosphorylation S485 0.170 -0.259 _AHS(ph)EKDQPPFGDSDDSVEADK_
MDC1 Phosphorylation S376 -0.196 -0.279 _GPGAPGLAHLQESQAGS(ph)DTDVEEGKAPQAVPLEK_
MDC1 Phosphorylation S793 -0.391 -0.332 _AIPGDQHPES(ph)PVHTEPM(ox)GIQGR_
MDC1 Phosphorylation S1399 -0.366 _NRS(ph)SGKTPETLVPTAPK_
MDC1 Phosphorylation T1589 -0.952 -0.451 _NQLVT(ph)PEPTSR_
MDC1 Phosphorylation T1488 -0.511 _SSVKTPET(ph)VVPTAPELQASASTDQPVTSEPTSR_
MDC1 Phosphorylation Y775 -0.566 _ESEDSETQPFDTHLEAY(ph)GPCLSPPR_
MDC1 Phosphorylation S1417 -0.579 _LEPS(ph)TSTDQPVT(ph)PEPTSQATR_
MDC1 Phosphorylation S1797 -0.582 -0.634 _S(ph)RFTPELQPK_
MDC1 Phosphorylation S780 -0.852 -0.642 _ESEDSETQPFDTHLEAYGPCLS(ph)PPR_
MDC1 Phosphorylation T331 -0.735 -0.646 _AQPFGFIDSDT(ph)DAEEERIPATPVVIPMKK_
MDC1 Phosphorylation S329 -0.069 -0.749 _AQPFGFIDS(ph)DTDAEEERIPATPVVIPMK_
MDC1 Phosphorylation S995 -0.793 _GQAS(ph)SPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGS(ph)PVSPR_
MDC1 Phosphorylation T1541 -1.076 _TPETVVPAAPELQPST(ph)STDQPVTPEPTSR_
MDC1 Phosphorylation T1239 -1.231 _SSVKT(ph)PEPVVPTAPELQPSTSTDQPVTSEPTYQATR_
MDC1 Phosphorylation T1608 -0.490 -1.272 _SSVKT(ph)PEPVVPTAPEPHPTTSTDQPVTPK_
MDC1 Phosphorylation T1384 -1.318 _NPESTVPIAPELPPSTSTEQPVT(ph)PEPTSR_
MDC1 Phosphorylation T1548 -1.262 -1.584 _TPETVVPAAPELQPSTSTDQPVT(ph)PEPTSR_
MDC1 Phosphorylation T1630 -1.705 _SSVKT(ph)PEPVVPTAPEPHPTTSTDQPVT(ph)PK_
MDC1 Phosphorylation T378 -0.401 _GPGAPGLAHLQESQAGSDT(ph)DVEEGK_
MDC1 Phosphorylation S453 0.346 _SQTTTERDS(ph)DTDVEEEELPVENR_
MDC1 Phosphorylation T455 -0.574 _SQTTTERDSDT(ph)DVEEEELPVENR_
MDC1 Ubiquitylation K472 -0.332 _EAVLK(gl)DHTK_
MDC1 Ubiquitylation K476 -0.040 _EAVLKDHTK(gl)IR_
MDC1 Phosphorylation S986 -1.929 _GQASSPTPEPGVGAGDLPGPTSAPVPS(ph)GSQSGGRGSPVSPR_
MDC1 Phosphorylation S1194 0.770 _S(ph)SVKTPETVVPTALELQPSTSTDRPVTSEPTSQATR_
MDC1 Phosphorylation T1198 0.898 _SSVKT(ph)PETVVPTALELQPSTSTDRPVTSEPTSQATR_
MDC1 Phosphorylation T1444 -0.989 _SSVKT(ph)PETVVPTAPELQPSTSTDQPVTPEPTSQATR_
MDC1 Phosphorylation T1466 5.092 _SSVKT(ph)PETVVPTAPELQPSTSTDQPVT(ph)PEPTSQATR_
MDC1 Ubiquitylation K1885 1.530 _TK(gl)LNQESTAPK_

Background Information for MDC1:


Pubmed-MDC1 »
Uniprot-MDC1 »
Biogrid-MDC1 »
ProteomicsDB-MDC1 »

Tumorportal-MDC1 »
COSMIC-MDC1 »
GenomeRNAi-MDC1 »
Genecards-MDC1


Protein-protein Interactions for MDC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4A Cat. description Hein, Mann, Cell 2015
Category members IP bait ESAM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3KBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MDC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FHA_dom IPR000253 2.3
Category members BRCT_dom IPR001357 1.59
Category members SMAD_FHA_domain IPR008984 0.86


Protein complexes (CORUM database) featuring MDC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5176 MGC1-DNA-PKcs-Ku complex Database 1.21
Category members Corum 2218 MDC1-MRE11-RAD50-NBS1 complex Database 1.09
Category members Corum 2217 MDC1-MRN-ATM-FANCD2 complex Database 1.08
Category members Corum 2775 MDC1-p53BP1-SMC1 complex Database 0.91
Category members Corum 2774 MDC1-H2AFX-TP53BP1 complex Database 0.66


Categories featuring MDC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0031573 intra-S DNA damage checkpoint Database 1.18
Category members GO Category GO:0005925 focal adhesion Database 0.68


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