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Query: LEPR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LEPR 0 0.456 -0.050 0.330

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LEPR Ubiquitylation K592 0.126 _MYEVYDAK(gl)SK_
LEPR Ubiquitylation K594 0.126 _MYEVYDAK(gl)SK_

Background Information for LEPR:


Pubmed-LEPR »
Uniprot-LEPR »
Biogrid-LEPR »
ProteomicsDB-LEPR »

Tumorportal-LEPR »
COSMIC-LEPR »
GenomeRNAi-LEPR »
Genecards-LEPR


Protein-protein Interactions for LEPR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTNL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LEPR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Fibronectin_type3 IPR003961 0.19
Category members IgC2-like_lig-bd IPR010457 0


Protein complexes (CORUM database) featuring LEPR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1091 SNX complex (SNX1a, SNX2, SNX4, LEPR) Database 0.05


Categories featuring LEPR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members Pathway Pathway_1184 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0 1.89
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0004896 cytokine receptor activity Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members Pathway Pathway_155 BIOCARTA_LEPTIN_PATHWAY 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members GO Category GO:0051346 negative regulation of hydrolase activity Database 0


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