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Query: LAMC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LAMC1 0 0.699 0.650 -1.240 -0.164 0.459

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LAMC1 Ubiquitylation K564 0.404 _YFIAPAK(gl)FLGK_

Background Information for LAMC1:


Pubmed-LAMC1 »
Uniprot-LAMC1 »
Biogrid-LAMC1 »
ProteomicsDB-LAMC1 »

Tumorportal-LAMC1 »
COSMIC-LAMC1 »
GenomeRNAi-LAMC1 »
Genecards-LAMC1


Protein-protein Interactions for LAMC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PHKG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLEC11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM175A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM175B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNLIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXLNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LAMC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF_laminin IPR002049 0.04
Category members Laminin_B_type_IV IPR000034 0
Category members Laminin_N IPR008211 0
Category members Laminin_B_subgr IPR018031 0


Protein complexes (CORUM database) featuring LAMC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2318 ITGA6-ITGB4-Laminin10/12 complex Database 0
Category members Corum 2319 ITGA6-ITGB4-Laminin10/12 complex Database 0


Categories featuring LAMC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0005201 extracellular matrix structural constituent Database 0.55
Category members GO Category GO:0005578 proteinaceous extracellular matrix Database 0.53
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0034446 substrate adhesion-dependent cell spreading Database 0.26
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0022617 extracellular matrix disassembly Database 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0043259 laminin-10 complex Database 0.04
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1290 PID_INTEGRIN4_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0005605 basal lamina Database 0
Category members GO Category GO:0005606 laminin-1 complex Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0031581 hemidesmosome assembly Database 0
Category members GO Category GO:0043208 glycosphingolipid binding Database 0
Category members GO Category GO:0043260 laminin-11 complex Database 0


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