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Query: KPNB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KPNB1 0 6.026 -1.100 2.030 0.513 -0.057 0.327 0.627 0.452

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KPNB1 Ubiquitylation K867 0.636 1.498 _TLATWATK(gl)ELR_
KPNB1 Ubiquitylation K835 -0.212 0.450 _DVLK(gl)LVEAR_
KPNB1 Ubiquitylation K68 0.403 0.420 _NSLTSK(gl)DPDIK_
KPNB1 Ubiquitylation K859 0.118 _AK(gl)TLATWATK_
KPNB1 Ubiquitylation K73 -0.134 _NSLTSKDPDIK(gl)AQYQQR_
KPNB1 Ubiquitylation K211 -0.036 _ANFDK(gl)ESER_
KPNB1 Ubiquitylation K549 -0.563 _DCYPAVQK(gl)TTLVIMER_

Background Information for KPNB1:


Pubmed-KPNB1 »
Uniprot-KPNB1 »
Biogrid-KPNB1 »
ProteomicsDB-KPNB1 »

Tumorportal-KPNB1 »
COSMIC-KPNB1 »
GenomeRNAi-KPNB1 »
Genecards-KPNB1


Protein-protein Interactions for KPNB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CETN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DLGAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF18B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait B2M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HP1BP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KPNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KPNB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83
Category members Armadillo IPR000225 1.58
Category members HEAT_type_2 IPR021133 0.74
Category members Importin-beta_N IPR001494 0


Protein complexes (CORUM database) featuring KPNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1554 RANBP1-RAN-KPNB1 complex Database 0.82


Categories featuring KPNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_1310 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 0 7.24
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0006607 NLS-bearing protein import into nucleus Database 1.48
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_955 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 0 0.51
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0000060 protein import into nucleus, translocation Database 0.42
Category members Pathway Pathway_1255 BIOCARTA_RANMS_PATHWAY 0 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0006610 ribosomal protein import into nucleus Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0008536 Ran GTPase binding Database 0.21
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members GO Category GO:0008139 nuclear localization sequence binding Database 0


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