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Query: JUP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
JUP 0 1.518 0.450 -0.350 0.431 -1.564
JUP 0 1.518 0.450 -0.350 0.075 -0.081 -1.243
JUP 0 1.518 0.450 -0.350 -0.128 -0.447 -0.022

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
JUP Phosphorylation S665 0.717 0.799 _RVS(ph)VELTNSLFK_
JUP Phosphorylation S182 0.349 _ALMGS(ph)PQLVAAVVR_
JUP Ubiquitylation K345 0.119 _VLSVCPSNK(gl)PAIVEAGGMQALGK_
JUP Ubiquitylation K385 0.114 0.056 _NLSDVATK(gl)QEGLESVLK_
JUP Ubiquitylation K171 -0.652 _AAMIVNQLSK(gl)K_
JUP Ubiquitylation K499 -1.010 _LLNQPNQWPLVK(gl)_

Background Information for JUP:


Pubmed-JUP »
Uniprot-JUP »
Biogrid-JUP »
ProteomicsDB-JUP »

Tumorportal-JUP »
COSMIC-JUP »
GenomeRNAi-JUP »
Genecards-JUP


Protein-protein Interactions for JUP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AXIN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CAT Cat. description Hein, Mann, Cell 2015
Category members IP bait CDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait COBLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MRPL9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait YEATS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf118 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OAZ3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDE4DIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PI4KA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD51AP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in JUP
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring JUP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31


Categories featuring JUP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0005915 zonula adherens Database 0.93
Category members GO Category GO:0007016 cytoskeletal anchoring at plasma membrane Database 0.74
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0030018 Z disc Database 0.32
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members GO Category GO:0030057 desmosome Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0002159 desmosome assembly Database 0.21
Category members GO Category GO:0003181 atrioventricular valve morphogenesis Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0007398 ectoderm development Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0016327 apicolateral plasma membrane Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0045294 alpha-catenin binding Database 0.03
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_1276 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway Database 0
Category members GO Category GO:0003308 negative regulation of Wnt signaling pathway involved in heart development Database 0
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0016331 morphogenesis of embryonic epithelium Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016342 catenin complex Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042307 positive regulation of protein import into nucleus Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0048599 oocyte development Database 0
Category members GO Category GO:0050982 detection of mechanical stimulus Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0


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