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Query: ITGA4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGA4 0 1.739 -0.620 0.820

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITGA4 Phosphorylation S1021 -0.095 1.014 _RDS(ph)WSYINSK_

Background Information for ITGA4:


Pubmed-ITGA4 »
Uniprot-ITGA4 »
Biogrid-ITGA4 »
ProteomicsDB-ITGA4 »

Tumorportal-ITGA4 »
COSMIC-ITGA4 »
GenomeRNAi-ITGA4 »
Genecards-ITGA4


Protein-protein Interactions for ITGA4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BTNL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CST9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAAA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPRK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGA4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FG-GAP IPR013517 0.3
Category members Int_alpha_beta-p IPR013519 0.1
Category members Integrin_alpha IPR000413 0.03
Category members Integrin_alpha-2 IPR013649 0.03


Protein complexes (CORUM database) featuring ITGA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1810 ITGA4-PXN-GIT1 complex Database 0.25
Category members Corum 2422 ITGA4-ITGB1-JAM2 complex Database 0.25
Category members Corum 2423 ITGA4-ITGB1-CD47 complex Database 0.25
Category members Corum 2424 ITGA4-ITGB1-CD63 complex Database 0.25
Category members Corum 2418 ITGA4-ITGB1 complex Database 0.08
Category members Corum 2417 ITGA4-ITGB1-EMILIN1 complex Database 0
Category members Corum 2419 ITGA4-ITGB1-CD81 complex Database 0
Category members Corum 2420 ITGA4-ITGB1-CD53 complex Database 0
Category members Corum 2421 ITGA4-ITGB1-VCAM1 complex Database 0
Category members Corum 2426 ITGA4-ITGB1-THBS1 complex Database 0
Category members Corum 2428 ITGA4-ITGB1-THBS2 complex Database 0


Categories featuring ITGA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_449 KEGG_HEMATOPOIETIC_CELL_LINEAGE 0 0.31
Category members Pathway Pathway_1132 KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0 0.3
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0060324 face development Database 0.08
Category members GO Category GO:0007157 heterophilic cell-cell adhesion Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1122 BIOCARTA_LYM_PATHWAY 0 0
Category members Pathway Pathway_1123 BIOCARTA_LAIR_PATHWAY 0 0
Category members Pathway Pathway_1160 PID_INTEGRIN5_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1285 BIOCARTA_MONOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members GO Category GO:0001968 fibronectin binding Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0
Category members GO Category GO:0060710 chorio-allantoic fusion Database 0


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