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Query: IQGAP3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IQGAP3 0 0.266 1.720 -1.070 0.165 0.274

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IQGAP3 Ubiquitylation K661 0.344 _ALESAMAKK(gl)_
IQGAP3 Phosphorylation T1426 -0.517 _SLT(ph)AHSLLPLAEK_

Background Information for IQGAP3:


Pubmed-IQGAP3 »
Uniprot-IQGAP3 »
Biogrid-IQGAP3 »
ProteomicsDB-IQGAP3 »

Tumorportal-IQGAP3 »
COSMIC-IQGAP3 »
GenomeRNAi-IQGAP3 »
Genecards-IQGAP3


Protein-protein Interactions for IQGAP3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TEN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEX19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IQGAP3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members WW_dom IPR001202 1.15
Category members CH-domain IPR001715 0.63
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RasGAP IPR001936 0.19
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members RasGAP_C IPR000593 0


Protein complexes (CORUM database) featuring IQGAP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IQGAP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0017016 Ras GTPase binding Database 1.28
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0008361 regulation of cell size Database 0.06
Category members GO Category GO:0005099 Ras GTPase activator activity Database 0.02
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0033601 positive regulation of mammary gland epithelial cell proliferation Database 0
Category members GO Category GO:0070371 ERK1 and ERK2 cascade Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0


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