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Query: GAPDH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GAPDH 0 3.101 0.130 0.380 0.283 0.870 0.760 -0.040 -0.473

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GAPDH Ubiquitylation K61 0.521 0.820 _FHGTVK(gl)AENGK_
GAPDH Ubiquitylation K263 -0.140 0.790 _VVK(gl)QASEGPLK_
GAPDH Ubiquitylation K145 0.536 0.707 _YDNSLK(gl)IISNASCTTNCLAPLAK_
GAPDH Ubiquitylation K219 0.588 _GALQNIIPASTGAAKAVGK(gl)_
GAPDH Ubiquitylation K194 0.139 0.426 _TVDGPSGK(gl)LWR_
GAPDH Ubiquitylation K215 0.068 0.425 _GALQNIIPASTGAAK(gl)AVGK_
GAPDH Ubiquitylation K259 -0.052 0.054 _LEKPAKYDDIK(gl)K_
GAPDH Ubiquitylation K260 0.061 -0.269 _LEKPAKYDDIKK(gl)_
GAPDH Ubiquitylation K66 -0.023 _FHGTVKAENGK(gl)_
GAPDH Ubiquitylation K86 0.473 _IK(gl)WGDAGAEYVVESTGVFTTMEK_
GAPDH Ubiquitylation K117 1.371 _AGAHLQGGAK(gl)R_
GAPDH Ubiquitylation K254 -0.005 _LEKPAK(gl)YDDIKK_

Background Information for GAPDH:


Pubmed-GAPDH »
Uniprot-GAPDH »
Biogrid-GAPDH »
ProteomicsDB-GAPDH »

Tumorportal-GAPDH »
COSMIC-GAPDH »
GenomeRNAi-GAPDH »
Genecards-GAPDH


Protein-protein Interactions for GAPDH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait GAPDH Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait RABGGTA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZIC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GAPDH
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Glyceraldehyde-3-P_DH_1 IPR006424 0
Category members GlycerAld_3-P_DH_NAD(P)-bd IPR020828 0
Category members GlycerAld_3-P_DH_cat IPR020829 0
Category members GlycerAld/Erythrose_P_DH IPR020831 0


Protein complexes (CORUM database) featuring GAPDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex Database 1.56
Category members Corum 5385 GAIT complex Database 1.27
Category members Corum 2936 Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1) Database 0


Categories featuring GAPDH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_59 BIOCARTA_GLYCOLYSIS_PATHWAY 0 1.96
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0006094 gluconeogenesis Database 1.42
Category members Pathway Pathway_33 REACTOME_GLUCONEOGENESIS 0 1.41
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_54 BIOCARTA_MTA3_PATHWAY 0 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0071346 cellular response to interferon-gamma Database 0.04
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members GO Category GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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