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Query: E2F3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
E2F3 0 -0.247 0.000 0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
E2F3 Ubiquitylation K188 -0.267 _TRYDTSLGLLTK(gl)K_
E2F3 Ubiquitylation K189 -0.267 _TRYDTSLGLLTK(gl)K_

Background Information for E2F3:


Pubmed-E2F3 »
Uniprot-E2F3 »
Biogrid-E2F3 »
ProteomicsDB-E2F3 »

Tumorportal-E2F3 »
COSMIC-E2F3 »
GenomeRNAi-E2F3 »
Genecards-E2F3


Protein-protein Interactions for E2F3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TFDP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFDP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in E2F3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members E2F_TDP IPR003316 0.45


Protein complexes (CORUM database) featuring E2F3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring E2F3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members Pathway Pathway_778 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX 0 0.1
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members Pathway Pathway_1253 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX 0 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members GO Category GO:0000085 mitotic G2 phase Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0


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