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Query: DLD

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DLD 0 1.653 -0.420 0.270 1.380 0.780 -1.052 0.824 0.231

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for DLD:


Pubmed-DLD »
Uniprot-DLD »
Biogrid-DLD »
ProteomicsDB-DLD »

Tumorportal-DLD »
COSMIC-DLD »
GenomeRNAi-DLD »
Genecards-DLD


Protein-protein Interactions for DLD
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait STAT5B Cat. description Hein, Mann, Cell 2015
Category members IP bait DLD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIAH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DLD
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pyr_OxRdtase_NAD-bd_dom IPR001327 0.03
Category members Pyridine_nuc-diS_OxRdtase_2 IPR000103 0
Category members Hg_reductase IPR000815 0
Category members GIDA-rel IPR002218 0
Category members FAD_bind_dom IPR003953 0
Category members Pyr_nucl-diS_OxRdtase_dimer IPR004099 0
Category members CHP00275_HI0933-like IPR004792 0
Category members FAD_pyr_nucl-diS_OxRdtase IPR013027 0
Category members FAD/NAD-linked_Rdtase_dimer IPR016156 0
Category members Pyr_nucl-diS_OxRdtase_FAD/NAD IPR023753 0


Protein complexes (CORUM database) featuring DLD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DLD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members Pathway Pathway_12 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE 0 1.87
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0006120 mitochondrial electron transport, NADH to ubiquinone Database 0.07
Category members Pathway Pathway_14 REACTOME_PYRUVATE_METABOLISM 0 0.05
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members Pathway Pathway_19 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 0 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members Disease phenotype Leigh_Syndrome_(nuclear_DNA_mutation) Leigh Syndrome (nuclear DNA mutation) Database 0.04
Category members GO Category GO:0048240 sperm capacitation Database 0.02
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_15 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 0 0
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_18 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM 0 0
Category members Pathway Pathway_20 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0006554 lysine catabolic process Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0009083 branched-chain amino acid catabolic process Database 0
Category members GO Category GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Database 0
Category members GO Category GO:0043159 acrosomal matrix Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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