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Query: DHCR24

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DHCR24 0 0.334 1.100 -0.830 0.024 -0.083

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DHCR24 Ubiquitylation K313 0.393 _HVENYLK(gl)TNR_
DHCR24 Ubiquitylation K76 -0.970 0.315 _VRDIQK(gl)QVR_
DHCR24 Ubiquitylation K254 -0.170 _GLEAICAK(gl)FTHESQR_
DHCR24 Ubiquitylation K367 -0.346 -0.263 _ISLLK(gl)LTQGETLR_
DHCR24 Ubiquitylation K459 -0.920 -0.275 _QLEK(gl)FVR_
DHCR24 Ubiquitylation K496 -0.539 -0.460 _EK(gl)LGCQDAFPEVYDK_
DHCR24 Ubiquitylation K509 -0.754 _LGCQDAFPEVYDK(gl)ICK_

Background Information for DHCR24:


Pubmed-DHCR24 »
Uniprot-DHCR24 »
Biogrid-DHCR24 »
ProteomicsDB-DHCR24 »

Tumorportal-DHCR24 »
COSMIC-DHCR24 »
GenomeRNAi-DHCR24 »
Genecards-DHCR24


Protein-protein Interactions for DHCR24
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP2A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBL Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHCR24 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DHCR24
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Oxid_FAD_bind_N IPR006094 0
Category members FAD-bd_2 IPR016166 0


Protein complexes (CORUM database) featuring DHCR24
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DHCR24
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0042987 amyloid precursor protein catabolic process Database 0.09
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Database 0.03
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members Pathway Pathway_162 KEGG_STEROID_BIOSYNTHESIS 0 0
Category members Pathway Pathway_164 REACTOME_CHOLESTEROL_BIOSYNTHESIS 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0008202 steroid metabolic process Database 0
Category members GO Category GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Database 0
Category members GO Category GO:0009888 tissue development Database 0
Category members GO Category GO:0016125 sterol metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Database 0
Category members GO Category GO:0030539 male genitalia development Database 0
Category members GO Category GO:0031639 plasminogen activation Database 0
Category members GO Category GO:0042605 peptide antigen binding Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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