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Query: DDX5

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX5 0 2.072 -1.650 2.390
DDX5 0 2.072 -1.650 2.390 -0.487 -0.664 -0.206 -0.502 -0.276

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX5 Ubiquitylation K523 -0.201 0.947 _GYSSLLK(gl)R_
DDX5 Ubiquitylation K351 -0.308 0.700 _TIVFVETK(gl)R_
DDX5 Ubiquitylation K197 -0.288 0.192 _LK(gl)STCIYGGAPK_
DDX5 Ubiquitylation K80 0.126 _SK(gl)EITVR_
DDX5 Ubiquitylation K207 -0.829 0.102 _STCIYGGAPK(gl)GPQIR_
DDX5 Ubiquitylation K437 -0.330 0.049 _STK(gl)TGTAYTFFTPNNIK_
DDX5 Ubiquitylation K340 -0.436 0.044 _LMEEIMSEK(gl)ENK_
DDX5 Ubiquitylation K343 0.044 _LMEEIMSEK(gl)ENK_
DDX5 Ubiquitylation K264 -1.652 _K(gl)IVDQIRPDR_
DDX5 Ubiquitylation K391 -1.312 _HGK(gl)APILIATDVASR_
DDX5 Ubiquitylation K470 -1.176 _EANQAINPK(gl)LLQLVEDR_

Background Information for DDX5:


Pubmed-DDX5 »
Uniprot-DDX5 »
Biogrid-DDX5 »
ProteomicsDB-DDX5 »

Tumorportal-DDX5 »
COSMIC-DDX5 »
GenomeRNAi-DDX5 »
Genecards-DDX5


Protein-protein Interactions for DDX5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDX17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDX5
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring DDX5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1332 Large Drosha complex Database 0.08
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07
Category members Corum 1148 snRNP-free U1A (SF-A) complex Database 0.05
Category members Corum 814 Postsplicing complex Database 0.01


Categories featuring DDX5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0000381 regulation of alternative mRNA splicing, via spliceosome Database 0.5
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0048306 calcium-dependent protein binding Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0003724 RNA helicase activity Database 0.07
Category members GO Category GO:0045069 regulation of viral genome replication Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_879 BIOCARTA_AKAP95_PATHWAY 0 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0
Category members GO Category GO:0036002 pre-mRNA binding Database 0
Category members GO Category GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0045667 regulation of osteoblast differentiation Database 0
Category members GO Category GO:0060765 regulation of androgen receptor signaling pathway Database 0


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