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Query: CPS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CPS1 0 -1.618 -0.030 -0.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CPS1 Phosphorylation S1278 -0.511 -1.077 _ASRSFPFVS(ph)K_

Background Information for CPS1:


Pubmed-CPS1 »
Uniprot-CPS1 »
Biogrid-CPS1 »
ProteomicsDB-CPS1 »

Tumorportal-CPS1 »
COSMIC-CPS1 »
GenomeRNAi-CPS1 »
Genecards-CPS1


Protein-protein Interactions for CPS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP1S2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3BP Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORMDL1;ORMDL2;ORMDL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACSM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGEF26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFB121 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXRED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIRREL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OTC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YBEY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CPS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CbamoylP_synth_lsu-like_ATP-bd IPR005479 0.91
Category members PreATP-grasp_dom IPR016185 0.62
Category members CarbamoylP_synth_lsu_N IPR005481 0.58
Category members ATP-grasp IPR011761 0.35
Category members ATP-grasp_carboxylate-amine IPR003135 0.3
Category members Dala_Dala_lig_C IPR011095 0.3
Category members GATASE IPR017926 0.04
Category members CarbamoylP_synth_ssu_N IPR002474 0
Category members CarbamoylP_synth_lsu_oligo IPR005480 0
Category members CbamoylP_synth_lsu_CPSase_dom IPR005483 0
Category members CarbamoylP_synth_ssu IPR006274 0
Category members CarbamoylP_synth_lsu IPR006275 0
Category members MGS-like_dom IPR011607 0
Category members Class_I_gatase-like IPR029062 0


Protein complexes (CORUM database) featuring CPS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CPS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0033762 response to glucagon Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005980 glycogen catabolic process Database 0.2
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0008716 D-alanine-D-alanine ligase activity Database 0.13
Category members GO Category GO:0014075 response to amine Database 0.11
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0000050 urea cycle Database 0.09
Category members GO Category GO:0071400 cellular response to oleic acid Database 0.08
Category members Pathway Pathway_393 KEGG_NITROGEN_METABOLISM 0 0.07
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_272 KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 0 0.04
Category members GO Category GO:0070365 hepatocyte differentiation Database 0.03
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_135 KEGG_ARGININE_AND_PROLINE_METABOLISM 0 0.01
Category members GO Category GO:0007494 midgut development Database 0.01
Category members GO Category GO:0006543 glutamine catabolic process Database 0
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members GO Category GO:0001101 response to acid Database 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0006807 nitrogen compound metabolic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010043 response to zinc ion Database 0
Category members GO Category GO:0016595 glutamate binding Database 0
Category members GO Category GO:0019240 citrulline biosynthetic process Database 0
Category members GO Category GO:0019433 triglyceride catabolic process Database 0
Category members GO Category GO:0032094 response to food Database 0
Category members GO Category GO:0034201 response to oleic acid Database 0
Category members GO Category GO:0042594 response to starvation Database 0
Category members GO Category GO:0043200 response to amino acid Database 0
Category members GO Category GO:0044344 cellular response to fibroblast growth factor stimulus Database 0
Category members GO Category GO:0045909 positive regulation of vasodilation Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050667 homocysteine metabolic process Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0055081 anion homeostasis Database 0
Category members GO Category GO:0060416 response to growth hormone Database 0
Category members GO Category GO:0070409 carbamoyl phosphate biosynthetic process Database 0
Category members GO Category GO:0071320 cellular response to cAMP Database 0
Category members GO Category GO:0071377 cellular response to glucagon stimulus Database 0


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