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Query: CFB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CFB 0 -6.502 -0.380 -0.210

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CFB Ubiquitylation K808 -6.292 _VASYGVK(gl)PR_

Background Information for CFB:


Pubmed-CFB »
Uniprot-CFB »
Biogrid-CFB »
ProteomicsDB-CFB »

Tumorportal-CFB »
COSMIC-CFB »
GenomeRNAi-CFB »
Genecards-CFB


Protein-protein Interactions for CFB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CFB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Compl_C2_B IPR011360 0.22
Category members Trypsin-like_Pept_dom IPR009003 0.04
Category members Peptidase_S1A IPR001314 0.03
Category members Peptidase_S1 IPR001254 0.01
Category members Sushi_SCR_CCP IPR000436 0
Category members VWF_A IPR002035 0


Protein complexes (CORUM database) featuring CFB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CFB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members Pathway Pathway_733 ST_G_ALPHA_S_PATHWAY 0 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Disease phenotype MACULAR_DEGENERATION_AGE-RELATED_1 MACULAR DEGENERATION AGE-RELATED 1 Database 0.1
Category members Pathway Pathway_735 ST_MYOCYTE_AD_PATHWAY 0 0.09
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0004252 serine-type endopeptidase activity Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members Pathway Pathway_306 ST_WNT_CA2_CYCLIC_GMP_PATHWAY 0 0.03
Category members Pathway Pathway_1189 KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 0 0
Category members Pathway Pathway_1297 REACTOME_COMPLEMENT_CASCADE 0 0
Category members Pathway Pathway_1298 BIOCARTA_COMP_PATHWAY 0 0
Category members Pathway Pathway_1300 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 0 0
Category members Pathway Pathway_1302 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_725 ST_GA12_PATHWAY 0 0
Category members GO Category GO:0001848 complement binding Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0006956 complement activation Database 0
Category members GO Category GO:0006957 complement activation, alternative pathway Database 0
Category members GO Category GO:0030449 regulation of complement activation Database 0


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