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Query: CBX5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CBX5 0 5.092 0.350 -0.490 0.332 -0.485 0.744 0.961 0.512

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CBX5 Ubiquitylation K102 1.233 1.344 _KSNFSNSADDIK(gl)SK_
CBX5 Ubiquitylation K154 0.568 0.740 _WKDTDEADLVLAK(gl)EANVK_
CBX5 Phosphorylation S14 -0.620 0.260 _RTADSSSS(ph)EDEEEYVVEK_
CBX5 Phosphorylation S92 0.064 -0.325 _RKS(ph)NFSNSADDIK_
CBX5 Ubiquitylation K32 1.081 _VVK(gl)GQVEYLLK_
CBX5 Ubiquitylation K68 1.329 _NLDCPELISEFMK(gl)K_
CBX5 Ubiquitylation K69 0.893 _NLDCPELISEFMKK(gl)_
CBX5 Ubiquitylation K91 1.360 _K(gl)SNFSNSADDIK_

Background Information for CBX5:


Pubmed-CBX5 »
Uniprot-CBX5 »
Biogrid-CBX5 »
ProteomicsDB-CBX5 »

Tumorportal-CBX5 »
COSMIC-CBX5 »
GenomeRNAi-CBX5 »
Genecards-CBX5


Protein-protein Interactions for CBX5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C9orf126;SCAI Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHAF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CHAMP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAU2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MIS12 Cat. description Hein, Mann, Cell 2015
Category members IP bait NLRP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP9 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPLX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DSN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ENSA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRCH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUV39H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUV39H2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF354C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF462 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF562 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF621 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CBX5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Chromo_domain/shadow IPR000953 2.84
Category members Chromodomain-like IPR016197 2.29
Category members Chromo_domain IPR023780 1.98
Category members Chromo_dom_subgr IPR017984 0.83
Category members Chromo_shadow_dom IPR008251 0.46


Protein complexes (CORUM database) featuring CBX5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1464 Mis12 centromere complex Database 0.08
Category members Corum 2763 MBD1-Suv39h1-HP1 complex Database 0.05


Categories featuring CBX5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005720 nuclear heterochromatin Database 1.41
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0035064 methylated histone residue binding Database 0.53
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0035097 histone methyltransferase complex Database 0.26
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0010369 chromocenter Database 0
Category members GO Category GO:0031618 nuclear centromeric heterochromatin Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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