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Query: CAD

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CAD 1 4.096 1.760 -0.990 -0.363 -0.027 0.051

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CAD Phosphorylation S1406 0.530 0.612 _RLS(ph)SFVTK_
CAD Ubiquitylation K760 0.489 _IGSCMK(gl)SVGEVMGIGR_
CAD Ubiquitylation K778 -0.005 _SFEEAFQK(gl)ALR_
CAD Phosphorylation S1859 -0.178 -0.084 _IHRAS(ph)DPGLPAEEPKEK_
CAD Ubiquitylation K1411 -0.215 -0.224 _RLSSFVTK(gl)GYR_
CAD Ubiquitylation K1309 0.012 -0.277 _AMLSTGFK(gl)IPK_
CAD Ubiquitylation K1211 -0.235 -0.502 _DDQLK(gl)VIECNVR_
CAD Ubiquitylation K1325 -0.719 -0.613 _NK(gl)SELLPTVR_
CAD Ubiquitylation K739 -0.732 -0.798 _NSVTGGTAAFEPSVDYCVVK(gl)IPR_
CAD Ubiquitylation K1119 -1.239 _FLSSAAAVSK(gl)EHPVVISK_
CAD Phosphorylation T1827 -1.407 _WPQGAVPQLPPSAPAT(ph)SEMTTTPERPR_
CAD Ubiquitylation K1657 2.804 -1.545 _LGPGK(gl)GEVRPELGSR_
CAD Ubiquitylation K1460 0.321 _VHVDCMTSQK(gl)LVR_

Background Information for CAD:


Pubmed-CAD »
Uniprot-CAD »
Biogrid-CAD »
ProteomicsDB-CAD »

Tumorportal-CAD »
COSMIC-CAD »
GenomeRNAi-CAD »
Genecards-CAD


Protein-protein Interactions for CAD
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ILK Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3BP Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM29 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015


Protein Domains in CAD
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CbamoylP_synth_lsu-like_ATP-bd IPR005479 0.91
Category members PreATP-grasp_dom IPR016185 0.62
Category members CarbamoylP_synth_lsu_N IPR005481 0.58
Category members ATP-grasp IPR011761 0.35
Category members ATP-grasp_carboxylate-amine IPR003135 0.3
Category members Dala_Dala_lig_C IPR011095 0.3
Category members ATP-grasp_RimK-type IPR013651 0.21
Category members GATASE IPR017926 0.04
Category members Asp_carbamoyltransf IPR002082 0
Category members CarbamoylP_synth_ssu_N IPR002474 0
Category members CarbamoylP_synth_lsu_oligo IPR005480 0
Category members CbamoylP_synth_lsu_CPSase_dom IPR005483 0
Category members Asp/Orn_carbamoylTrfase IPR006130 0
Category members Asp_carbamoyltransf_Asp/Orn-bd IPR006131 0
Category members Asp/Orn_carbamoyltranf_P-bd IPR006132 0
Category members CarbamoylP_synth_ssu IPR006274 0
Category members CarbamoylP_synth_lsu IPR006275 0
Category members Amidohydro_1 IPR006680 0
Category members Metal-dep_hydrolase_composite IPR011059 0
Category members MGS-like_dom IPR011607 0
Category members Class_I_gatase-like IPR029062 0


Protein complexes (CORUM database) featuring CAD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CAD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006541 glutamine metabolic process Database 0.47
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0008716 D-alanine-D-alanine ligase activity Database 0.13
Category members GO Category GO:0014075 response to amine Database 0.11
Category members GO Category GO:0016597 amino acid binding Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0046134 pyrimidine nucleoside biosynthetic process Database 0.05
Category members GO Category GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Database 0.04
Category members Pathway Pathway_272 KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 0 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0006543 glutamine catabolic process Database 0
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_278 REACTOME_PYRIMIDINE_METABOLISM 0 0
Category members GO Category GO:0006206 pyrimidine nucleobase metabolic process Database 0
Category members GO Category GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process Database 0
Category members GO Category GO:0006228 UTP biosynthetic process Database 0
Category members GO Category GO:0006520 cellular amino acid metabolic process Database 0
Category members GO Category GO:0006807 nitrogen compound metabolic process Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0016743 carboxyl- or carbamoyltransferase activity Database 0
Category members GO Category GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Database 0
Category members GO Category GO:0017144 drug metabolic process Database 0
Category members GO Category GO:0031000 response to caffeine Database 0
Category members GO Category GO:0033574 response to testosterone Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043195 terminal bouton Database 0
Category members GO Category GO:0044205 'de novo' UMP biosynthetic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051414 response to cortisol Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0070409 carbamoyl phosphate biosynthetic process Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0


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