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Query: ARHGAP35

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARHGAP35 0 1.393 1.030 -0.620 -0.833 0.397 0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARHGAP35 Phosphorylation S1179 0.400 0.591 _TSFSVGS(ph)DDELGPIR_
ARHGAP35 Phosphorylation S1150 1.218 0.094 _KVS(ph)IVSKPVLYR_
ARHGAP35 Phosphorylation S975 -0.388 -0.423 _AGS(ph)PLCNSNLQDSEEDIEPSYSLFR_
ARHGAP35 Phosphorylation S1072 -0.719 _SVS(ph)SSPWLPQDGFDPSDYAEPMDAVVKPR_

Background Information for ARHGAP35:


Pubmed-ARHGAP35 »
Uniprot-ARHGAP35 »
Biogrid-ARHGAP35 »
ProteomicsDB-ARHGAP35 »

Tumorportal-ARHGAP35 »
COSMIC-ARHGAP35 »
GenomeRNAi-ARHGAP35 »
Genecards-ARHGAP35


Protein-protein Interactions for ARHGAP35
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in ARHGAP35
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members FF_domain IPR002713 1.23
Category members Small_GTPase IPR001806 0.65
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RhoGAP_dom IPR000198 0


Protein complexes (CORUM database) featuring ARHGAP35
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARHGAP35
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1172 PID_RHOA_REG_PATHWAY 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043010 camera-type eye development Database 0.05
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0005100 Rho GTPase activator activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0043116 negative regulation of vascular permeability Database 0


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