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Query: AK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AK2 1 1.285 0.380 -0.820 1.981 0.248 -0.715

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AK2 Ubiquitylation K65 -0.229 _LK(gl)ATMDAGK_
AK2 Ubiquitylation K63 -0.244 _AMVASGSELGKK(gl)_
AK2 Ubiquitylation K28 -2.435 -1.363 _AVLLGPPGAGK(gl)GTQAPR_

Background Information for AK2:


Pubmed-AK2 »
Uniprot-AK2 »
Biogrid-AK2 »
ProteomicsDB-AK2 »

Tumorportal-AK2 »
COSMIC-AK2 »
GenomeRNAi-AK2 »
Genecards-AK2


Protein-protein Interactions for AK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AIFM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPT Cat. description Hein, Mann, Cell 2015
Category members IP bait NRIP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait AIFM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Adenylat/UMP-CMP_kin IPR000850 0
Category members Adenyl_kin_sub IPR006259 0
Category members Adenylate_kinase_lid-dom IPR007862 0


Protein complexes (CORUM database) featuring AK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5856 AK2-FADD-caspase-10 (AFAC10) complex Database 0


Categories featuring AK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0019205 nucleobase-containing compound kinase activity Database 0.2
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0006172 ADP biosynthetic process Database 0.04
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members GO Category GO:0004017 adenylate kinase activity Database 0
Category members GO Category GO:0006119 oxidative phosphorylation Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0016776 phosphotransferase activity, phosphate group as acceptor Database 0
Category members GO Category GO:0036126 sperm flagellum Database 0
Category members GO Category GO:0046033 AMP metabolic process Database 0
Category members GO Category GO:0046034 ATP metabolic process Database 0
Category members GO Category GO:0046060 dATP metabolic process Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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