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Query: AGRN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AGRN 0 -0.879 -0.130 0.060 -0.939

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for AGRN:


Pubmed-AGRN »
Uniprot-AGRN »
Biogrid-AGRN »
ProteomicsDB-AGRN »

Tumorportal-AGRN »
COSMIC-AGRN »
GenomeRNAi-AGRN »
Genecards-AGRN


Protein-protein Interactions for AGRN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OLFM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFP41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AGRN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members Kazal_dom IPR002350 0.12
Category members Laminin_G IPR001791 0.06
Category members EGF_laminin IPR002049 0.04
Category members Fol_N IPR003645 0.01
Category members SEA_dom IPR000082 0
Category members FacI_MAC IPR003884 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members TIMP-like_OB-fold IPR008993 0


Protein complexes (CORUM database) featuring AGRN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AGRN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_73 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 0 1.71
Category members GO Category GO:0030203 glycosaminoglycan metabolic process Database 1.44
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members Pathway Pathway_471 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 0 0.6
Category members Pathway Pathway_79 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 0 0.49
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0035374 chondroitin sulfate binding Database 0.44
Category members GO Category GO:0030204 chondroitin sulfate metabolic process Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_478 REACTOME_HS_GAG_BIOSYNTHESIS 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_479 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS 0 0.21
Category members GO Category GO:0006024 glycosaminoglycan biosynthetic process Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0001523 retinoid metabolic process Database 0.1
Category members GO Category GO:0050808 synapse organization Database 0.08
Category members Disease phenotype Presynaptic_congenital_myasthenic_syndromes Presynaptic congenital myasthenic syndromes Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0033691 sialic acid binding Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0006027 glycosaminoglycan catabolic process Database 0.05
Category members Pathway Pathway_1009 REACTOME_NCAM1_INTERACTIONS 0 0.04
Category members Pathway Pathway_76 REACTOME_HS_GAG_DEGRADATION 0 0.03
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Disease phenotype MYASTHENIA_LIMB-GIRDLE_FAMILIAL MYASTHENIA LIMB-GIRDLE FAMILIAL Database 0
Category members Disease phenotype Postsynaptic_congenital_myasthenic_syndromes Postsynaptic congenital myasthenic syndromes Database 0
Category members GO Category GO:0002162 dystroglycan binding Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0005605 basal lamina Database 0
Category members GO Category GO:0007009 plasma membrane organization Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007213 G-protein coupled acetylcholine receptor signaling pathway Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0008582 regulation of synaptic growth at neuromuscular junction Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0043113 receptor clustering Database 0
Category members GO Category GO:0043236 laminin binding Database 0
Category members GO Category GO:0043395 heparan sulfate proteoglycan binding Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0045162 clustering of voltage-gated sodium channels Database 0
Category members GO Category GO:0045213 neurotransmitter receptor metabolic process Database 0
Category members GO Category GO:0051491 positive regulation of filopodium assembly Database 0


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