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Query: ABL2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ABL2 0 0.984 0.050 -0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ABL2 Phosphorylation S631 0.529 0.416 _DKS(ph)PSSLLEDAK_
ABL2 Phosphorylation S620 0.568 0.091 _GAQASSGS(ph)PALPR_
ABL2 Phosphorylation S817 0.028 0.055 _TVS(ph)TSSQPEENVDR_
ABL2 Phosphorylation S936 -0.218 -0.547 _VPVLIS(ph)PTLK_
ABL2 Phosphorylation S618 -0.733 _GAQASS(ph)GSPALPR_
ABL2 Phosphorylation S634 0.322 _DKSPSS(ph)LLEDAK_
ABL2 Phosphorylation S781 0.421 _S(ph)NSTSSM(ox)SSGLPEQDR_
ABL2 Phosphorylation S783 -0.171 _SNS(ph)TSSMSSGLPEQDR_

Background Information for ABL2:


Pubmed-ABL2 »
Uniprot-ABL2 »
Biogrid-ABL2 »
ProteomicsDB-ABL2 »

Tumorportal-ABL2 »
COSMIC-ABL2 »
GenomeRNAi-ABL2 »
Genecards-ABL2


Protein-protein Interactions for ABL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ABI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BAG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ABL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members SH3-like_bac-type IPR003646 0
Category members F-actin_binding IPR015015 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring ABL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1700 ABL2-HRAS-RIN1 complex Database 0


Categories featuring ABL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0051017 actin filament bundle assembly Database 0.47
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0003785 actin monomer binding Database 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010506 regulation of autophagy Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0030100 regulation of endocytosis Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0051353 positive regulation of oxidoreductase activity Database 0
Category members GO Category GO:0071300 cellular response to retinoic acid Database 0


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