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Query: AAK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AAK1 0 2.034 1.900 -1.150
AAK1 0 2.034 1.900 -1.150 0.289 -0.421

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AAK1 Phosphorylation S652 0.769 1.397 _S(ph)TQLLQAAAAEASLNK_
AAK1 Phosphorylation T653 0.769 1.397 _S(ph)TQLLQAAAAEASLNK_
AAK1 Phosphorylation S947 -0.044 0.120 _S(ph)ESNEDLFGLVPFDEITGSQQQK_
AAK1 Phosphorylation T1014 -0.576 0.108 _TLKPTYRT(ph)PER_
AAK1 Phosphorylation S949 0.168 -0.189 _SES(ph)NEDLFGLVPFDEITGSQQQK_
AAK1 Phosphorylation S624 -0.737 -0.516 _VGSLT(ph)PPSS(ph)PK_
AAK1 Phosphorylation T620 -0.540 -0.524 _VGSLT(ph)PPSS(ph)PK_
AAK1 Phosphorylation S623 -0.540 -0.550 _VGSLT(ph)PPS(ph)SPK_
AAK1 Phosphorylation T605 -0.689 _VQT(ph)TPPPAVQGQK_
AAK1 Phosphorylation T606 -0.648 -1.206 _VQTT(ph)PPPAVQGQK_

Background Information for AAK1:


Pubmed-AAK1 »
Uniprot-AAK1 »
Biogrid-AAK1 »
ProteomicsDB-AAK1 »

Tumorportal-AAK1 »
COSMIC-AAK1 »
GenomeRNAi-AAK1 »
Genecards-AAK1


Protein-protein Interactions for AAK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait REPS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AAK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring AAK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AAK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005112 Notch binding Database 0.14
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0019897 extrinsic to plasma membrane Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0035612 AP-2 adaptor complex binding Database 0
Category members GO Category GO:0043195 terminal bouton Database 0
Category members GO Category GO:0045747 positive regulation of Notch signaling pathway Database 0


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