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Query: ZFHX3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZFHX3 0 -2.001 -0.200 0.390 -0.903 -0.394

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZFHX3 Phosphorylation S425 -0.531 -0.563 _TPITSVPLGPLAS(ph)SPTK_

Background Information for ZFHX3:


Pubmed-ZFHX3 »
Uniprot-ZFHX3 »
Biogrid-ZFHX3 »
ProteomicsDB-ZFHX3 »

Tumorportal-ZFHX3 »
COSMIC-ZFHX3 »
GenomeRNAi-ZFHX3 »
Genecards-ZFHX3


Protein-protein Interactions for ZFHX3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait WRAP53 Cat. description Hein, Mann, Cell 2015


Protein Domains in ZFHX3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92
Category members Homeobox_dom IPR001356 0.63
Category members Znf_U1 IPR003604 0
Category members Homeodomain-like IPR009057 0
Category members Adenylate_cyclase-assoc_CAP_N IPR013992 0


Protein complexes (CORUM database) featuring ZFHX3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ZFHX3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0045662 negative regulation of myoblast differentiation Database 0
Category members GO Category GO:0045663 positive regulation of myoblast differentiation Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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