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Query: WNK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WNK1 1 6.762 -2.390 5.600 0.546 0.639
WNK1 1 6.762 -0.180 0.010 0.546 0.639

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WNK1 Phosphorylation S2530 0.202 -0.225 _DVDDGSGSPHS(ph)PHQLSSK_
WNK1 Phosphorylation S2509 -0.298 _KEKPELSEPSHLNGPS(ph)SDPEAAFLSR_
WNK1 Phosphorylation S2510 -0.532 -0.298 _KEKPELSEPSHLNGPSS(ph)DPEAAFLSR_
WNK1 Phosphorylation S2503 -0.810 -0.764 _KEKPELSEPS(ph)HLNGPSSDPEAAFLSR_
WNK1 Phosphorylation S2476 -0.727 -0.899 _KEGPVAS(ph)PPFMDLEQAVLPAVIPK_
WNK1 Phosphorylation S2527 -0.349 _DVDDGSGS(ph)PHSPHQLSSK_

Background Information for WNK1:


Pubmed-WNK1 »
Uniprot-WNK1 »
Biogrid-WNK1 »
ProteomicsDB-WNK1 »

Tumorportal-WNK1 »
COSMIC-WNK1 »
GenomeRNAi-WNK1 »
Genecards-WNK1


Protein-protein Interactions for WNK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AAMP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AARSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BAG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WNK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase_OSR1/WNK_CCT IPR024678 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring WNK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1121 WNK1-OSR1 complex Database 0.26
Category members Corum 1123 WNK1-SPAk complex Database 0.17


Categories featuring WNK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006811 ion transport Database 0.18
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members Disease phenotype Hereditary_sensory_and_autonomic_neuropathy_type_2 Hereditary sensory and autonomic neuropathy type 2 Database 0.09
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004860 protein kinase inhibitor activity Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0003084 positive regulation of systemic arterial blood pressure Database 0
Category members GO Category GO:0010923 negative regulation of phosphatase activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0050794 regulation of cellular process Database 0


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