bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: WHSC1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WHSC1 2 8.092 1.030 -0.990
WHSC1 2 8.092 1.030 -0.990 0.496 0.141

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WHSC1 Ubiquitylation K292 1.695 4.410 _SLVAFEGEGQFEK(gl)LCQESAK_
WHSC1 Ubiquitylation K588 0.161 _SQAATK(gl)NLSDACKPLK_
WHSC1 Phosphorylation T49 -1.049 _GIGT(ph)PPNT(ph)TPIK_
WHSC1 Phosphorylation T54 -1.049 _GIGT(ph)PPNTT(ph)PIK_
WHSC1 Phosphorylation T483 -0.839 _RIQDPTEDAEAEDT(ph)PRK_
WHSC1 Phosphorylation S557 1.350 _SSS(ph)PSASLTENEVK_

Background Information for WHSC1:


Pubmed-WHSC1 »
Uniprot-WHSC1 »
Biogrid-WHSC1 »
ProteomicsDB-WHSC1 »

Tumorportal-WHSC1 »
COSMIC-WHSC1 »
GenomeRNAi-WHSC1 »
Genecards-WHSC1


Protein-protein Interactions for WHSC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C16orf88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CNBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGCR8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLTSCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPATCH4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3HAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF692 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WHSC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91
Category members PWWP_dom IPR000313 0.63
Category members HMG_box_dom IPR009071 0.31
Category members SET_dom IPR001214 0.29
Category members Post-SET_dom IPR003616 0.03
Category members Znf_RING IPR001841 0
Category members AWS_dom IPR006560 0


Protein complexes (CORUM database) featuring WHSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring WHSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Disease phenotype Wolf-Hirschhorn_syndrome Wolf-Hirschhorn syndrome Database 0
Category members GO Category GO:0003149 membranous septum morphogenesis Database 0
Category members GO Category GO:0003289 atrial septum primum morphogenesis Database 0
Category members GO Category GO:0003290 atrial septum secundum morphogenesis Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0060348 bone development Database 0


.

© Copyright Svejstrup Laboratory 2015