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Query: VAMP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VAMP2 0 1.973
VAMP2 0 1.973 0.418

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VAMP2 Ubiquitylation K54 0.408 0.792 _VNVDK(gl)VLER_
VAMP2 Phosphorylation S58 -0.407 0.612 _ADALQAGAS(ph)QFETSAAK_
VAMP2 Ubiquitylation K61 0.558 0.387 _VLERDQK(gl)LSELDDR_
VAMP2 Phosphorylation S63 0.374 _ADALQAGASQFETS(ph)AAK_

Background Information for VAMP2:


Pubmed-VAMP2 »
Uniprot-VAMP2 »
Biogrid-VAMP2 »
ProteomicsDB-VAMP2 »

Tumorportal-VAMP2 »
COSMIC-VAMP2 »
GenomeRNAi-VAMP2 »
Genecards-VAMP2


Protein-protein Interactions for VAMP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait VAMP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MUC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDFY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VAMP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Synaptobrevin IPR001388 0
Category members Synaptobrevin/VAMP_met/fun IPR016444 0


Protein complexes (CORUM database) featuring VAMP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1137 SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3) Database 0.13
Category members Corum 1138 SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4) Database 0.13
Category members Corum 793 SNARE complex (VAMP2, SNAP25, STX1a, CPLX1) Database 0.13
Category members Corum 1139 SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4) Database 0.04
Category members Corum 1874 SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13) Database 0
Category members Corum 707 SNARE complex (VAMP2, SNAP25, STX13) Database 0
Category members Corum 731 SNARE complex (STX4, SNAP23, VAMP2) Database 0
Category members Corum 794 SNARE complex (VAMP2, SNAP25, STX1a, CPLX2) Database 0
Category members Corum 797 SNARE complex (STX11, VAMP2, SNAP23) Database 0


Categories featuring VAMP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_1261 KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 0 1.52
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030672 synaptic vesicle membrane Database 1.16
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0031201 SNARE complex Database 0.49
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0043001 Golgi to plasma membrane protein transport Database 0.32
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_1262 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 0 0.2
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex Database 0.13
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0017075 syntaxin-1 binding Database 0.09
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members Pathway Pathway_1263 REACTOME_BOTULINUM_NEUROTOXICITY 0 0.07
Category members Pathway Pathway_1264 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.07
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members GO Category GO:0030667 secretory granule membrane Database 0.05
Category members GO Category GO:0060203 clathrin-sculpted glutamate transport vesicle membrane Database 0.05
Category members GO Category GO:0070083 clathrin-sculpted monoamine transport vesicle membrane Database 0.05
Category members Pathway Pathway_389 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 0 0.04
Category members Pathway Pathway_404 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.04
Category members Pathway Pathway_397 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.01
Category members Pathway Pathway_1256 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members Pathway Pathway_390 REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members Pathway Pathway_712 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0007269 neurotransmitter secretion Database 0
Category members GO Category GO:0014047 glutamate secretion Database 0
Category members GO Category GO:0016079 synaptic vesicle exocytosis Database 0
Category members GO Category GO:0017022 myosin binding Database 0
Category members GO Category GO:0017156 calcium ion-dependent exocytosis Database 0
Category members GO Category GO:0017157 regulation of exocytosis Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0042589 zymogen granule membrane Database 0
Category members GO Category GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Database 0
Category members GO Category GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex Database 0


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