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Query: USP22

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP22 0 2.218 -1.620 2.280 -0.102 -0.073 -0.208

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP22 Ubiquitylation K35 0.350 _VDNWK(gl)QNLR_
USP22 Ubiquitylation K166 -0.657 -0.098 _K(gl)ITSNCTIGLR_
USP22 Ubiquitylation K159 -0.035 -0.557 _ELELLK(gl)HNPK_
USP22 Ubiquitylation K152 -1.310 -0.895 _FSTWEPTK(gl)R_
USP22 Ubiquitylation K382 -0.028 -1.061 _IK(gl)CSGCHSYQESTK_

Background Information for USP22:


Pubmed-USP22 »
Uniprot-USP22 »
Biogrid-USP22 »
ProteomicsDB-USP22 »

Tumorportal-USP22 »
COSMIC-USP22 »
GenomeRNAi-USP22 »
Genecards-USP22


Protein-protein Interactions for USP22
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AASDHPPT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATXN7L3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3AR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD274 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CREB3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ENPP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM63B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMED2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC5CL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP22
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53
Category members Znf_UBP IPR001607 0.05


Protein complexes (CORUM database) featuring USP22
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP22
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0016579 protein deubiquitination Database 1.32
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0016574 histone ubiquitination Database 0.2
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0000124 SAGA complex Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0010485 H4 histone acetyltransferase activity Database 0
Category members GO Category GO:0016578 histone deubiquitination Database 0
Category members GO Category GO:0043967 histone H4 acetylation Database 0
Category members GO Category GO:0070461 SAGA-type complex Database 0


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