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Query: UPF3B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UPF3B 0 -0.001 -0.820 0.890 -0.652 -0.447

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UPF3B Ubiquitylation K196 0.208 _K(gl)TTPLLSFLK_

Background Information for UPF3B:


Pubmed-UPF3B »
Uniprot-UPF3B »
Biogrid-UPF3B »
ProteomicsDB-UPF3B »

Tumorportal-UPF3B »
COSMIC-UPF3B »
GenomeRNAi-UPF3B »
Genecards-UPF3B


Protein-protein Interactions for UPF3B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait UPF3B Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC60 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FADS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RLIM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC4A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF280A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UPF3B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nonsense_mediated_decay_UPF3 IPR005120 0.18


Protein complexes (CORUM database) featuring UPF3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 822 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Database 1.39
Category members Corum 785 Exon junction complex Database 0.29
Category members Corum 813 Upf complex (UPF1, UPF2, UPF3b) Database 0.26
Category members Corum 814 Postsplicing complex Database 0.01


Categories featuring UPF3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members GO Category GO:0005487 nucleocytoplasmic transporter activity Database 0.79
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members Disease phenotype X-linked_intellectual_disability_with_marfanoid_habitus X-linked intellectual disability with marfanoid habitus Database 0.05
Category members Disease phenotype X-linked_non-syndromic_intellectual_disability X-linked non-syndromic intellectual disability Database 0.01
Category members GO Category GO:0045727 positive regulation of translation Database 0


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