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Query: TPM3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPM3 1 1.442 2.410 -1.030 -1.315
TPM3 1 1.442 2.410 -1.030 -0.178 0.366 -0.380 0.330 -1.062

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TPM3 Ubiquitylation K11 0.368 1.125 _(ac)AGITTIEAVK(gl)R_
TPM3 Ubiquitylation K228 1.242 0.668 _CTK(gl)EEHLCTQR_
TPM3 Ubiquitylation K116 -0.031 _MELQEIQLKEAK(gl)_
TPM3 Ubiquitylation K223 0.612 _TIDDLEDK(gl)LK_
TPM3 Ubiquitylation K225 0.564 _TIDDLEDKLK(gl)CTK_

Background Information for TPM3:


Pubmed-TPM3 »
Uniprot-TPM3 »
Biogrid-TPM3 »
ProteomicsDB-TPM3 »

Tumorportal-TPM3 »
COSMIC-TPM3 »
GenomeRNAi-TPM3 »
Genecards-TPM3


Protein-protein Interactions for TPM3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ADD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MIS12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPM3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tropomyosin IPR000533 0.08
Category members HR1_rho-bd IPR011072 0.07


Protein complexes (CORUM database) featuring TPM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Disease phenotype THYROID_CARCINOMA_PAPILLARY THYROID CARCINOMA PAPILLARY Database 0.72
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0002102 podosome Database 0.3
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members Disease phenotype Inflammatory_myofibroblastic_tumor Inflammatory myofibroblastic tumor Database 0.23
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Disease phenotype Congenital_fiber-type_disproportion_myopathy Congenital fiber-type disproportion myopathy Database 0.04
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_198 KEGG_CARDIAC_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Disease phenotype Cap_myopathy Cap myopathy Database 0
Category members Disease phenotype Childhood-onset_nemaline_myopathy Childhood-onset nemaline myopathy Database 0
Category members Disease phenotype Intermediate_nemaline_myopathy Intermediate nemaline myopathy Database 0
Category members Disease phenotype MYOPATHY_CONGENITAL_WITH_FIBER-TYPE_DISPROPORTION MYOPATHY CONGENITAL WITH FIBER-TYPE DISPROPORTION Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0005862 muscle thin filament tropomyosin Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0006937 regulation of muscle contraction Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0


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