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Query: TFRC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TFRC 0 -0.124 -0.840 0.870 -1.270 -0.277
TFRC 0 -0.124 -0.840 0.870 0.348 -1.075 -0.602

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TFRC Ubiquitylation K371 1.291 _MVTSESK(gl)NVK_
TFRC Ubiquitylation K374 1.291 _MVTSESK(gl)NVK_
TFRC Ubiquitylation K53 -1.280 0.042 _LAVDEEENADNNTK(gl)ANVTKPK_

Background Information for TFRC:


Pubmed-TFRC »
Uniprot-TFRC »
Biogrid-TFRC »
ProteomicsDB-TFRC »

Tumorportal-TFRC »
COSMIC-TFRC »
GenomeRNAi-TFRC »
Genecards-TFRC


Protein-protein Interactions for TFRC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait ERBB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GJB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPSS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDGFRA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait SLITRK4 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015


Protein Domains in TFRC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_M28 IPR007484 0
Category members Protease-assoc_domain IPR003137 0
Category members TFR-like_dimer_dom IPR007365 0


Protein complexes (CORUM database) featuring TFRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1104 SNX complex (SNX1a, SNX2, SNX4, TFRC) Database 0


Categories featuring TFRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_449 KEGG_HEMATOPOIETIC_CELL_LINEAGE 0 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_192 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING 0 0
Category members Pathway Pathway_193 REACTOME_IRON_UPTAKE_AND_TRANSPORT 0 0
Category members GO Category GO:0004998 transferrin receptor activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0006879 cellular iron ion homeostasis Database 0
Category members GO Category GO:0030316 osteoclast differentiation Database 0
Category members GO Category GO:0033572 transferrin transport Database 0
Category members GO Category GO:0045780 positive regulation of bone resorption Database 0


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