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Query: STX4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STX4 0 0.245 1.010 -1.210 -0.201 -0.827

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STX4 Ubiquitylation K58 0.607 0.599 _LGNK(gl)VQELEK_
STX4 Ubiquitylation K54 -0.229 _QTIVK(gl)LGNK_
STX4 Ubiquitylation K102 -0.242 _LQLK(gl)AIEPQKEEADENYNSVNTR_
STX4 Ubiquitylation K108 0.674 _AIEPQK(gl)EEADENYNSVNTR_

Background Information for STX4:


Pubmed-STX4 »
Uniprot-STX4 »
Biogrid-STX4 »
ProteomicsDB-STX4 »

Tumorportal-STX4 »
COSMIC-STX4 »
GenomeRNAi-STX4 »
Genecards-STX4


Protein-protein Interactions for STX4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AAGAB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPAGT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPRC5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IPPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPPR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC7A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STXBP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STXBP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAMP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STX4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members T_SNARE_dom IPR000727 0.54
Category members Syntaxin_N IPR006011 0.14
Category members t-SNARE IPR010989 0.04


Protein complexes (CORUM database) featuring STX4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1169 SNARE complex (STX4, VAMP8, VAMP3, SNAP23) Database 0.32
Category members Corum 730 SNARE complex (STX4, SNAP23, VAMP1) Database 0.27
Category members Corum 733 SNARE complex (STX4, VAMP1, VAMP7) Database 0.27
Category members Corum 731 SNARE complex (STX4, SNAP23, VAMP2) Database 0


Categories featuring STX4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members Pathway Pathway_1261 KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 0 1.52
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0031201 SNARE complex Database 0.49
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_1262 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 0 0.2
Category members GO Category GO:0005484 SNAP receptor activity Database 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0035749 myelin sheath adaxonal region Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_1263 REACTOME_BOTULINUM_NEUROTOXICITY 0 0.07
Category members GO Category GO:0000149 SNARE binding Database 0.05
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members GO Category GO:0005773 vacuole Database 0
Category members GO Category GO:0006836 neurotransmitter transport Database 0
Category members GO Category GO:0042581 specific granule Database 0
Category members GO Category GO:0043219 lateral loop Database 0


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