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Query: SPTAN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPTAN1 1 4.624 1.040 -0.790
SPTAN1 1 4.624 1.040 -0.790 -0.323 -0.738 0.512 0.509

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPTAN1 Phosphorylation S1029 1.169 1.417 _LDPAQS(ph)ASRENLLEEQGSIALR_
SPTAN1 Phosphorylation S1031 1.169 1.397 _LDPAQSAS(ph)RENLLEEQGSIALR_
SPTAN1 Phosphorylation S1217 0.717 0.823 _WRS(ph)LQQLAEER_
SPTAN1 Ubiquitylation K2057 1.535 0.543 _HVQSK(gl)AIEAR_
SPTAN1 Ubiquitylation K1193 0.677 0.204 _TASPWK(gl)SAR_
SPTAN1 Ubiquitylation K1187 0.393 -0.095 _DETDSK(gl)TASPWK_
SPTAN1 Ubiquitylation K864 -0.012 _GNAMVEEGHFAAEDVKAK(gl)_

Background Information for SPTAN1:


Pubmed-SPTAN1 »
Uniprot-SPTAN1 »
Biogrid-SPTAN1 »
ProteomicsDB-SPTAN1 »

Tumorportal-SPTAN1 »
COSMIC-SPTAN1 »
GenomeRNAi-SPTAN1 »
Genecards-SPTAN1


Protein-protein Interactions for SPTAN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ADD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1279 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait VCL Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF187 Cat. description Hein, Mann, Cell 2015


Protein Domains in SPTAN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0
Category members EF_hand_dom IPR002048 0
Category members Spectrin_alpha_SH3 IPR013315 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring SPTAN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 5604 Emerin complex 1 Database 0.62
Category members Corum 5608 Emerin architectural complex Database 0.15
Category members Corum 5606 Emerin-actin-NMI-(alphaII)spectrin complex Database 0


Categories featuring SPTAN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members GO Category GO:0030507 spectrin binding Database 1.12
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0008091 spectrin Database 0.43
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_1018 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 0 0.11
Category members GO Category GO:0032437 cuticular plate Database 0.03
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1287 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 0 0
Category members Disease phenotype Early_infantile_epileptic_encephalopathy Early infantile epileptic encephalopathy Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0051693 actin filament capping Database 0


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