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Query: SPAST

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPAST 1 3.072 -1.590 2.900

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPAST Phosphorylation S268 0.172 _APS(ph)YSGLSMVSGVK_

Background Information for SPAST:


Pubmed-SPAST »
Uniprot-SPAST »
Biogrid-SPAST »
ProteomicsDB-SPAST »

Tumorportal-SPAST »
COSMIC-SPAST »
GenomeRNAi-SPAST »
Genecards-SPAST


Protein-protein Interactions for SPAST
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait FOSL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait LCK Cat. description Hein, Mann, Cell 2015
Category members IP bait LYPLAL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NLRP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN23 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPAST Cat. description Hein, Mann, Cell 2015
Category members IP bait TGS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS4B Cat. description Hein, Mann, Cell 2015
Category members IP bait RNF111 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPAST
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DNA_helicase_Holl-junc_RuvB_N IPR008824 1.05
Category members AAA+_ATPase IPR003593 0.38
Category members ATPase_AAA_core IPR003959 0.14
Category members MIT IPR007330 0


Protein complexes (CORUM database) featuring SPAST
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPAST
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0009378 four-way junction helicase activity Database 1.06
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0001578 microtubule bundle formation Database 0.49
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0006888 ER to Golgi vesicle-mediated transport Database 0.28
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0007109 cytokinesis, completion of separation Database 0
Category members GO Category GO:0008568 microtubule-severing ATPase activity Database 0
Category members GO Category GO:0031117 positive regulation of microtubule depolymerization Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0034214 protein hexamerization Database 0
Category members GO Category GO:0043014 alpha-tubulin binding Database 0
Category members GO Category GO:0051013 microtubule severing Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0


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