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Query: SMN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMN1 0 3.759 -1.430 1.720 0.023 0.246 -1.731
SMN1 0 3.759 -0.560 0.640 0.023 0.246 -1.731

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMN1 Ubiquitylation K45 0.101 1.114 _AYDK(gl)AVASFK_
SMN1 Phosphorylation S31 0.980 _RGTGQSDDS(ph)DIWDDTALIK_
SMN1 Phosphorylation S28 0.885 0.944 _GTGQS(ph)DDSDIWDDTALIK_
SMN1 Ubiquitylation K93 0.896 _NTAASLQQWK(gl)VGDK_
SMN1 Phosphorylation S8 0.239 0.738 _(ac)AMSSGGS(ph)GGGVPEQEDSVLFR_
SMN1 Phosphorylation T25 1.306 0.581 _GT(ph)GQSDDSDIWDDTALIK_
SMN1 Phosphorylation S4 0.158 0.444 _(ac)AMS(ph)SGGSGGGVPEQEDSVLFR_
SMN1 Phosphorylation S5 0.453 0.382 _(ac)AMSS(ph)GGSGGGVPEQEDSVLFR_
SMN1 Ubiquitylation K209 -0.581 -0.285 _LGPGK(gl)PGLK_
SMN1 Ubiquitylation K83 -0.049 -0.330 _K(gl)NTAASLQQWK_
SMN1 Ubiquitylation K51 -0.448 _AVASFK(gl)HALK_
SMN1 Ubiquitylation K65 -0.724 _NGDICETSGK(gl)PK_
SMN1 Ubiquitylation K179 -1.678 _SPGNK(gl)SDNIKPK_

Background Information for SMN1:


Pubmed-SMN1 »
Uniprot-SMN1 »
Biogrid-SMN1 »
ProteomicsDB-SMN1 »

Tumorportal-SMN1 »
COSMIC-SMN1 »
GenomeRNAi-SMN1 »
Genecards-SMN1


Protein-protein Interactions for SMN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GEMIN5 Cat. description Hein, Mann, Cell 2015
Category members IP bait GEMIN7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNRNP70 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRAP Cat. description Hein, Mann, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tudor IPR002999 0.28
Category members Survival_motor_neuron IPR010304 0


Protein complexes (CORUM database) featuring SMN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1751 SMN complex Database 0.37
Category members Corum 3284 SMN complex (GEMIN5,2,3,4, SMN) Database 0.23
Category members Corum 3298 SMN complex (GEMIN2,5, SMN) Database 0.2
Category members Corum 1746 SMN containing complex Database 0.19
Category members Corum 1143 SMN complex Database 0.14
Category members Corum 1752 SMN complex Database 0.11
Category members Corum 1142 SMN complex Database 0
Category members Corum 3098 TIM50a-SMN1 complex Database 0
Category members Corum 3118 SMN1-SIP1-SNRP complex Database 0
Category members Corum 824 Anti-SMN protein complex Database 0
Category members Corum 832 Anti-Sm protein complex Database 0


Categories featuring SMN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_887 REACTOME_METABOLISM_OF_NON_CODING_RNA 0 4.38
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0000245 spliceosomal complex assembly Database 0.39
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0000387 spliceosomal snRNP assembly Database 0.04
Category members Disease phenotype Proximal_spinal_muscular_atrophy_type_1 Proximal spinal muscular atrophy type 1 Database 0
Category members Disease phenotype Proximal_spinal_muscular_atrophy_type_2 Proximal spinal muscular atrophy type 2 Database 0
Category members Disease phenotype Proximal_spinal_muscular_atrophy_type_3 Proximal spinal muscular atrophy type 3 Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0034660 ncRNA metabolic process Database 0


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