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bioLOGIC Data

Query: SF3B1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
SF3B1	0	1.397			0.308	-0.445	-0.096	-0.608	-0.188

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
SF3B1	Ubiquitylation	K793	0.904	0.908	_VVK(gl)QCCGTDGVEANYIK_
SF3B1	Ubiquitylation	K1025		0.848	_LTPILK(gl)NR_
SF3B1	Ubiquitylation	K1292		0.731	_IYNDDK(gl)NTYIR_
SF3B1	Ubiquitylation	K963	1.062	0.292	_TAVVMK(gl)TCQEEK_
SF3B1	Phosphorylation	S488	0.467	-0.012	_LLVDVDESTLS(ph)PEEQKER_
SF3B1	Phosphorylation	S308	-0.512	-0.240	_DTPGHGS(ph)GWAETPRTDR_
SF3B1	Ubiquitylation	K1014		-0.389	_MTPPIK(gl)DLLPR_
SF3B1	Phosphorylation	T278	-0.033	-0.482	_GDTPGHAT(ph)PGHGGATSSAR_
SF3B1	Phosphorylation	T273	-0.351	-0.627	_GDT(ph)PGHATPGHGGATSSAR_
SF3B1	Phosphorylation	S129	-0.787	-0.713	_TMIIS(ph)PERLDPFADGGK_
SF3B1	Phosphorylation	T326	-1.194	-0.893	_GGDSIGET(ph)PT(ph)PGASK_
SF3B1	Phosphorylation	T313	-0.638	-0.898	_DTPGHGSGWAET(ph)PR_
SF3B1	Phosphorylation	T227	-1.216	-0.904	_LSSWDQAETPGHT(ph)PSLR_
SF3B1	Phosphorylation	S349		-0.947	_SRWDETPASQMGGS(ph)TPVLTPGK_
SF3B1	Phosphorylation	T350	-0.911	-0.979	_SRWDETPASQMGGST(ph)PVLTPGK_
SF3B1	Phosphorylation	T303		-1.006	_TERDT(ph)PGHGSGWAETPR_
SF3B1	Phosphorylation	T211	-0.765	-1.099	_WDQTADQT(ph)PGAT(ph)PK_
SF3B1	Phosphorylation	T223	-0.989	-1.111	_LSSWDQAET(ph)PGHTPSLR_
SF3B1	Phosphorylation	T235		-1.156	_WDET(ph)PGR_
SF3B1	Phosphorylation	T434	-0.601	-1.311	_LTAT(ph)PTPLGGMTGFHMQTEDR_
SF3B1	Phosphorylation	T432	-1.068	-1.330	_KLT(ph)ATPTPLGGM(ox)TGFHM(ox)QTEDR_
SF3B1	Phosphorylation	T328	-1.194	-1.428	_GGDSIGET(ph)PT(ph)PGASK_
SF3B1	Phosphorylation	T207	-1.127	-1.868	_WDQTADQT(ph)PGAT(ph)PK_
SF3B1	Phosphorylation	T142	-0.892	-2.157	_TMIIS(ph)PERLDPFADGGKT(ph)PDPK_
SF3B1	Ubiquitylation	K333	-1.360		_GGDSIGETPTPGASK(gl)R_

Background Information for SF3B1:

Pubmed-SF3B1 »

Uniprot-SF3B1 »

Biogrid-SF3B1 »

ProteomicsDB-SF3B1 »

Tumorportal-SF3B1 »

COSMIC-SF3B1 »

GenomeRNAi-SF3B1 »

Genecards-SF3B1

Protein-protein Interactions for SF3B1

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait ECT2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EMC2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ENTHD2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait JUNB	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait KIF7	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait KIFC1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait KPNA1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MMGT1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MYO1C	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NAF1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NES	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PIGS	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait UGGT1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait XRCC3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ZBTB33	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CCDC97	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait E4F1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait HIST1H1E	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PPAN	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PRR11	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RBM17	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RBM7	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RPS2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RPS8	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RRS1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPA1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPE	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPF	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPG	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPN	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait U2AF2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait ZCRB1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait ZRSR2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in SF3B1

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	ARM-type_fold	IPR016024	9.26

Protein complexes (CORUM database) featuring SF3B1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	351	Spliceosome	Database	9.3
Category members	Corum	1181	C complex spliceosome	Database	2.39
Category members	Corum	1183	CDC5L complex	Database	2.07
Category members	Corum	2755	17S U2 snRNP	Database	1.77
Category members	Corum	430	18S U11/U12 snRNP	Database	0.29
Category members	Corum	1737	SF3b complex	Database	0.08

Categories featuring SF3B1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	DDR Literature	pubmedid:24332808	Marechal et al., 2014 RPA-mediated recruitment		INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0010467	gene expression	Database	INF
Category members	Pathway	Pathway_373	REACTOME_MRNA_PROCESSING	0	12.92
Category members	Pathway	Pathway_380	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	0	12.24
Category members	GO Category	GO:0008380	RNA splicing	Database	10.77
Category members	DDR Literature	pubmedid:TBD1_UV_decreased	Elia et al, 2015 UV decreased acetylation events	Elia et al.	10.54
Category members	GO Category	GO:0005488	binding	Database	9.32
Category members	Pathway	Pathway_851	KEGG_SPLICEOSOME	0	7.94
Category members	GO Category	GO:0000398	mRNA splicing, via spliceosome	Database	7.06
Category members	Pathway	Pathway_377	REACTOME_MRNA_SPLICING	0	6.99
Category members	GO Category	GO:0003682	chromatin binding	Database	6.07
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	GO Category	GO:0016607	nuclear speck	Database	4.84
Category members	GO Category	GO:0005681	spliceosomal complex	Database	3.88
Category members	DDR Literature	pubmedid:19647519	Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation		3.6
Category members	GO Category	GO:0071013	catalytic step 2 spliceosome	Database	2.28
Category members	Pathway	Pathway_372	REACTOME_MRNA_SPLICING_MINOR_PATHWAY	0	1.52
Category members	Human mutations	Broad_cancer_genes	Broad cancer genes (Lawrence et al., 2014)	literature	1.14
Category members	Human mutations	pubmedid:24460190	The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014).	Research article	0.88
Category members	GO Category	GO:0000375	RNA splicing, via transesterification reactions	Database	0.73
Category members	GO Category	GO:0005689	U12-type spliceosomal complex	Database	0.29
Category members	GO Category	GO:0009952	anterior/posterior pattern specification	Database	0.06